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2015 ; 6
(ä): 469
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English Wikipedia
Induction of Regulatory T Cells by Intravenous Immunoglobulin: A Bridge between
Adaptive and Innate Immunity
#MMPMID26441974
Kaufman GN
; Massoud AH
; Dembele M
; Yona M
; Piccirillo CA
; Mazer BD
Front Immunol
2015[]; 6
(ä): 469
PMID26441974
show ga
Intravenous immunoglobulin (IVIg) is a polyclonal immunoglobulin G preparation
with potent immunomodulatory properties. The mode of action of IVIg has been
investigated in multiple disease states, with various mechanisms described to
account for its benefits. Recent data indicate that IVIg increases both the
number and the suppressive capacity of regulatory T cells, a subpopulation of T
cells that are essential for immune homeostasis. IVIg alters dendritic cell
function, cytokine and chemokine networks, and T lymphocytes, leading to
development of regulatory T cells. The ability of IVIg to influence Treg
induction has been shown both in animal models and in human diseases. In this
review, we discuss data on the potential mechanisms contributing to the
interaction between IVIg and the regulatory T-cell compartment.