Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.celrep.2015.02.034 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.02.034 C4565776!4565776!25772356     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25772356.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2015 ; 10 (10): 1681-91 Nephropedia Template TP {{tp|p=25772356|t=2015. Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research |pdf=|usr=}}{{25772356}} gab.com Text Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25772356 #FOAvip In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-On/Tet-Off systems. The wide range of direct effects of tetracycline use has, however, not been fully appreciated. We show here that these antibiotics induce a mitonuclear protein imbalance through their effects on mitochondrial translation, an effect that likely reflects the evolutionary relationship between mitochondria and proteobacteria. Tetracyclines, Even at low concentrations, tetracyclines induce mitochondrial proteotoxic stress, leading to changes in nuclear gene expression and altered mitochondrial dynamics and function in commonly used cell types, as well as worms, flies, mice, and plants. Since tetracyclines are so widely applied in research, scientists should be aware of their potentially confounding effects on experimental results. Furthermore, these results caution against extensive use of tetracyclines in livestock due to potential downstream impacts on the environment and human health. Twit Text FOAVip Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25772356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25772356 #FOAvip English Wikipedia <ref>{{Cite pmid|25772356}}</ref> Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research #MMPMID25772356 Moullan N; Mouchiroud L; Wang X; Ryu D; Williams EG; Mottis A; Jovaisaite V; Frochaux MV; Quiros PM; Deplancke B; Houtkooper RH; Auwerx J Cell Rep 2015[Mar]; 10 (10): 1681-91 PMID25772356show ga In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-On/Tet-Off systems. The wide range of direct effects of tetracycline use has, however, not been fully appreciated. We show here that these antibiotics induce a mitonuclear protein imbalance through their effects on mitochondrial translation, an effect that likely reflects the evolutionary relationship between mitochondria and proteobacteria. Tetracyclines, Even at low concentrations, tetracyclines induce mitochondrial proteotoxic stress, leading to changes in nuclear gene expression and altered mitochondrial dynamics and function in commonly used cell types, as well as worms, flies, mice, and plants. Since tetracyclines are so widely applied in research, scientists should be aware of their potentially confounding effects on experimental results. Furthermore, these results caution against extensive use of tetracyclines in livestock due to potential downstream impacts on the environment and human health. äTetracyclines disturb mitochondrial function across eukaryotic models:(epmc).pdf DeepDyve Pubget Overpricing