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10.1002/jcb.25205 http://scihub22266oqcxt.onion/10.1002/jcb.25205 C4565736!4565736!25914241     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Biochem 2015 ; 116 (11): 2598-609 Nephropedia Template TP {{tp|p=25914241|t=2015. Notch signaling promotes osteoclast maturation and resorptive activity |pdf=|usr=}}{{25914241}} gab.com Text Notch signaling promotes osteoclast maturation and resorptive activity JO: J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=25914241 #FOAvip The role of Notch signaling in osteoclast differentiation is controversial with conflicting experimental evidence indicating both stimulatory and inhibitory roles. Differences in experimental protocols and in vivo versus in vitro models may explain the discrepancies between studies. In this study, we investigated cell autonomous roles of Notch signaling in osteoclast differentiation and function by altering Notch signaling during osteoclast differentiation using stimulation with immobilized ligands Jagged1 or Delta-like1 or by suppression with ?-secretase inhibitor DAPT or transcriptional inhibitor SAHM1. Stimulation of Notch signaling in committed osteoclast precursors resulted in larger osteoclasts with a greater number of nuclei and resorptive activity whereas suppression resulted in smaller osteoclasts with fewer nuclei and suppressed resorptive activity. Conversely, stimulation of Notch signaling in osteoclast precursors prior to induction of osteoclastogenesis resulted in fewer osteoclasts. Our data support a mechanism of context-specific Notch signaling effects wherein Notch stimulation inhibits commitment to osteoclast differentiation, but enhances the maturation and function of committed precursors. Twit Text FOAVip Notch signaling promotes osteoclast maturation and resorptive activity ????J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=25914241 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25914241 #FOAvip English Wikipedia <ref>{{Cite pmid|25914241}}</ref> Notch signaling promotes osteoclast maturation and resorptive activity #MMPMID25914241 Ashley JW; Ahn J; Hankenson KD J Cell Biochem 2015[Nov]; 116 (11): 2598-609 PMID25914241show ga The role of Notch signaling in osteoclast differentiation is controversial with conflicting experimental evidence indicating both stimulatory and inhibitory roles. Differences in experimental protocols and in vivo versus in vitro models may explain the discrepancies between studies. In this study, we investigated cell autonomous roles of Notch signaling in osteoclast differentiation and function by altering Notch signaling during osteoclast differentiation using stimulation with immobilized ligands Jagged1 or Delta-like1 or by suppression with ?-secretase inhibitor DAPT or transcriptional inhibitor SAHM1. Stimulation of Notch signaling in committed osteoclast precursors resulted in larger osteoclasts with a greater number of nuclei and resorptive activity whereas suppression resulted in smaller osteoclasts with fewer nuclei and suppressed resorptive activity. Conversely, stimulation of Notch signaling in osteoclast precursors prior to induction of osteoclastogenesis resulted in fewer osteoclasts. Our data support a mechanism of context-specific Notch signaling effects wherein Notch stimulation inhibits commitment to osteoclast differentiation, but enhances the maturation and function of committed precursors. äNotch signaling promotes osteoclast maturation and resorptive activity(epmc).pdf DeepDyve Pubget Overpricing