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10.1155/2015/129612 http://scihub22266oqcxt.onion/10.1155/2015/129612 C4564588!4564588!26413502     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26413502|t=2015. Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents |pdf=|usr=}}{{26413502}} gab.com Text Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26413502 #FOAvip Opioids reduce injury from myocardial ischemia-reperfusion in humans. In experimental models, this mechanism involves GSK3? inhibition. HSP90 regulates mitochondrial protein import, with GSK3? inhibition increasing HSP90 mitochondrial content. Therefore, we determined whether morphine-induced cardioprotection is mediated by HSP90 and if the protective effect is downstream of GSK3? inhibition. Male Sprague-Dawley rats, aged 8?10 weeks, were subjected to an in vivo myocardial ischemia-reperfusion injury protocol involving 30 minutes of ischemia followed by 2 hours of reperfusion. Hemodynamics were continually monitored and myocardial infarct size determined. Rats received morphine (0.3?mg/kg), the GSK3? inhibitor, SB216763 (0.6?mg/kg), or saline, 10 minutes prior to ischemia. Some rats received selective HSP90 inhibitors, radicicol (0.3?mg/kg), or deoxyspergualin (DSG, 0.6?mg/kg) alone or 5 minutes prior to morphine or SB216763. Morphine reduced myocardial infarct size when compared to control (42 ± 2% versus 60 ± 1%). This protection was abolished by prior treatment of radicicol or DSG (59 ± 1%, 56 ± 2%). GSK3? inhibition also reduced myocardial infarct size (41 ± 2%) with HSP90 inhibition by radicicol or DSG partially inhibiting SB216763-induced infarct size reduction (54 ± 3%, 47 ± 1%, resp.). These data suggest that opioid-induced cardioprotection is mediated by HSP90. Part of this protection afforded by HSP90 is downstream of GSK3?, potentially via the HSP-TOM mitochondrial import pathway. Twit Text FOAVip Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26413502 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26413502 #FOAvip English Wikipedia <ref>{{Cite pmid|26413502}}</ref> Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents #MMPMID26413502 Small BA; Lu Y; Hsu AK; Gross GJ; Gross ER Biomed Res Int 2015[]; 2015 (ä): ä PMID26413502show ga Opioids reduce injury from myocardial ischemia-reperfusion in humans. In experimental models, this mechanism involves GSK3? inhibition. HSP90 regulates mitochondrial protein import, with GSK3? inhibition increasing HSP90 mitochondrial content. Therefore, we determined whether morphine-induced cardioprotection is mediated by HSP90 and if the protective effect is downstream of GSK3? inhibition. Male Sprague-Dawley rats, aged 8?10 weeks, were subjected to an in vivo myocardial ischemia-reperfusion injury protocol involving 30 minutes of ischemia followed by 2 hours of reperfusion. Hemodynamics were continually monitored and myocardial infarct size determined. Rats received morphine (0.3?mg/kg), the GSK3? inhibitor, SB216763 (0.6?mg/kg), or saline, 10 minutes prior to ischemia. Some rats received selective HSP90 inhibitors, radicicol (0.3?mg/kg), or deoxyspergualin (DSG, 0.6?mg/kg) alone or 5 minutes prior to morphine or SB216763. Morphine reduced myocardial infarct size when compared to control (42 ± 2% versus 60 ± 1%). This protection was abolished by prior treatment of radicicol or DSG (59 ± 1%, 56 ± 2%). GSK3? inhibition also reduced myocardial infarct size (41 ± 2%) with HSP90 inhibition by radicicol or DSG partially inhibiting SB216763-induced infarct size reduction (54 ± 3%, 47 ± 1%, resp.). These data suggest that opioid-induced cardioprotection is mediated by HSP90. Part of this protection afforded by HSP90 is downstream of GSK3?, potentially via the HSP-TOM mitochondrial import pathway. äMorphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in (epmc).pdf DeepDyve Pubget Overpricing