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10.1038/nbt.3289 http://scihub22266oqcxt.onion/10.1038/nbt.3289 C4564351!4564351!26237516     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biotechnol 2015 ; 33 (9): 980-4 Nephropedia Template TP {{tp|p=26237516|t=2015. High-throughput determination of RNA structure by proximity ligation |pdf=|usr=}}{{26237516}} gab.com Text High-throughput determination of RNA structure by proximity ligation JO: Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=26237516 #FOAvip We present an unbiased method to globally resolve RNA structures through pairwise contact measurements between interacting regions. RNA Proximity Ligation (RPL) uses proximity ligation of native RNA followed by deep sequencing to yield chimeric reads with ligation junctions in the vicinity of structurally proximate bases. We apply RPL in both baker's yeast (Saccharomyces cerevisiae) and human cells and generate contact probability maps for ribosomal and other abundant RNAs, including yeast snoRNAs, the RNA subunit of the signal recognition particle, and the yeast U2 spliceosomal RNA homolog. RPL measurements correlate with established secondary structures for these RNA molecules, including stem-loop structures and long-range pseudoknots. We anticipate that RPL will complement the current repertoire of computational and experimental approaches in enabling the high-throughput determination of secondary and tertiary RNA structures. Twit Text FOAVip High-throughput determination of RNA structure by proximity ligation ????Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=26237516 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26237516 #FOAvip English Wikipedia <ref>{{Cite pmid|26237516}}</ref> High-throughput determination of RNA structure by proximity ligation #MMPMID26237516 Ramani V; Qiu R; Shendure J Nat Biotechnol 2015[Sep]; 33 (9): 980-4 PMID26237516show ga We present an unbiased method to globally resolve RNA structures through pairwise contact measurements between interacting regions. RNA Proximity Ligation (RPL) uses proximity ligation of native RNA followed by deep sequencing to yield chimeric reads with ligation junctions in the vicinity of structurally proximate bases. We apply RPL in both baker's yeast (Saccharomyces cerevisiae) and human cells and generate contact probability maps for ribosomal and other abundant RNAs, including yeast snoRNAs, the RNA subunit of the signal recognition particle, and the yeast U2 spliceosomal RNA homolog. RPL measurements correlate with established secondary structures for these RNA molecules, including stem-loop structures and long-range pseudoknots. We anticipate that RPL will complement the current repertoire of computational and experimental approaches in enabling the high-throughput determination of secondary and tertiary RNA structures. äHigh-throughput determination of RNA structure by proximity ligation (epmc).pdf DeepDyve Pubget Overpricing