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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Lipidol
2015 ; 26
(5
): 412-9
Nephropedia Template TP
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Exosomes: emerging roles in communication between blood cells and vascular
tissues during atherosclerosis
#MMPMID26309202
Huber HJ
; Holvoet P
Curr Opin Lipidol
2015[Oct]; 26
(5
): 412-9
PMID26309202
show ga
PURPOSE OF REVIEW: Microvesicles, in general, and exosomes together with their
delivered content in particular, are now being widely recognized as key players
in atherosclerosis. We have previously reviewed the role of microvesicles in
atherosclerosis pathogenesis, diagnosis and therapy. Here, we focus on the roles
of exosomes and discuss their emergent role in mediating activation and response
to inflammation, vessel infiltration and induction of coagulation. We will
finally give an outlook to discuss novel detection techniques and systems biology
based data analyses to investigate exosome-mediated cell-to-cell communication.
RECENT FINDINGS: Recent research points to a role of exosomes in delivering
apoptotic and inflammatory content between blood cells and vascular cells, with a
potential contribution of exosomes secreted by adipose tissue. An
atheroprotective role of exosomes in response to coagulation that may contrast
with the procoagulatory role of platelet-derived larger microvesicles is
envisaged. New detection and separation methods and systems biology techniques
are emerging. CONCLUSION: We project that the development of novel detection,
separation and analysis mechanism and systems-based analysis methods will further
unravel the paracrine and endocrine 'communication protocol' between cellular
players in atherosclerosis, mediating inflammation, oxidative stress and
apoptosis.