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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Crit+Rev+Biochem+Mol+Biol
2013 ; 48
(3
): 289-99
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gab.com Text
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Human RECQL5: guarding the crossroads of DNA replication and transcription and
providing backup capability
#MMPMID23627586
Popuri V
; Tadokoro T
; Croteau DL
; Bohr VA
Crit Rev Biochem Mol Biol
2013[May]; 48
(3
): 289-99
PMID23627586
show ga
DNA helicases are ubiquitous enzymes that catalyze unwinding of duplex DNA and
function in all metabolic processes in which access to single-stranded DNA is
required, including DNA replication, repair, recombination and RNA transcription.
RecQ helicases are a conserved family of DNA helicases that display highly
specialized and vital roles in the maintenance of genome stability. Mutations in
three of the five human RecQ helicases, BLM, WRN and RECQL4 are associated with
the genetic disorders Bloom syndrome, Werner syndrome and Rothmund-Thomson
syndrome that are characterized by chromosomal instability, premature aging and
predisposition to cancer. The biological role of human RECQL5 is only partially
understood and RECQL5 has not yet been associated with any human disease.
Illegitimate recombination and replication stress are hallmarks of human cancers
and common instigators for genomic instability and cell death. Recql5 knockout
mice are cancer prone and show increased chromosomal instability.
Recql5-deficient mouse embryonic fibroblasts are sensitive to camptothecin and
display elevated levels of sister chromatid exchanges. Unlike other human RecQ
helicases, RECQL5 is recruited to single-stranded DNA breaks and is also proposed
to play an essential role in RNA transcription. Here, we review the established
roles of RECQL5 at the cross roads of DNA replication, recombination and
transcription, and propose that human RECQL5 provides important backup functions
in the absence of other DNA helicases.
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