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10.1038/ncomms9094 http://scihub22266oqcxt.onion/10.1038/ncomms9094 C4563812!4563812!26348915     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): 8094 Nephropedia Template TP {{tp|p=26348915|t=2015. In vivo capture and label-free detection of early metastatic cells |pdf=|usr=}}{{26348915}} gab.com Text In vivo capture and label-free detection of early metastatic cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26348915 #FOAvip Breast cancer is a leading cause of death for women, with mortality resulting from metastasis. Metastases are often detected once tumor cells affect the function of solid organs, with a high disease burden limiting effective treatment. Here we report a method for the early detection of metastasis using an implanted scaffold to recruit and capture metastatic cells in vivo, which achieves high cell densities and reduces the tumor burden within solid organs 10-fold. Recruitment is associated with infiltration of immune cells, which include Gr1hiCD11b+ cells. We identify metastatic cells in the scaffold through a label-free detection system using inverse-spectroscopic optical coherence tomography, which identifies changes to nanoscale tissue architecture associated with the presence of tumor cells. For patients at risk of recurrence, scaffold implantation following completion of primary therapy has the potential to identify metastatic disease at the earliest stage, enabling initiation of therapy while the disease burden is low. Twit Text FOAVip In vivo capture and label-free detection of early metastatic cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26348915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26348915 #FOAvip English Wikipedia <ref>{{Cite pmid|26348915}}</ref> In vivo capture and label-free detection of early metastatic cells #MMPMID26348915 Azarin SM; Yi J; Gower RM; Aguado BA; Sullivan ME; Goodman AG; Jiang EJ; Rao SS; Ren Y; Tucker SL; Backman V; Jeruss JS; Shea LD Nat Commun 2015[]; 6 (ä): 8094 PMID26348915show ga Breast cancer is a leading cause of death for women, with mortality resulting from metastasis. Metastases are often detected once tumor cells affect the function of solid organs, with a high disease burden limiting effective treatment. Here we report a method for the early detection of metastasis using an implanted scaffold to recruit and capture metastatic cells in vivo, which achieves high cell densities and reduces the tumor burden within solid organs 10-fold. Recruitment is associated with infiltration of immune cells, which include Gr1hiCD11b+ cells. We identify metastatic cells in the scaffold through a label-free detection system using inverse-spectroscopic optical coherence tomography, which identifies changes to nanoscale tissue architecture associated with the presence of tumor cells. For patients at risk of recurrence, scaffold implantation following completion of primary therapy has the potential to identify metastatic disease at the earliest stage, enabling initiation of therapy while the disease burden is low. äIn vivo capture and label-free detection of early metastatic cells (epmc).pdf DeepDyve Pubget Overpricing