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2015 ; 7
(9
): a015719
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Cell Division Modes and Cleavage Planes of Neural Progenitors during Mammalian
Cortical Development
#MMPMID26330517
Matsuzaki F
; Shitamukai A
Cold Spring Harb Perspect Biol
2015[Sep]; 7
(9
): a015719
PMID26330517
show ga
During mammalian brain development, neural progenitor cells undergo symmetric
proliferative divisions followed by asymmetric neurogenic divisions. The division
mode of these self-renewing progenitors, together with the cell fate of their
progeny, plays critical roles in determining the number of neurons and,
ultimately, the size of the adult brain. In the past decade, remarkable progress
has been made toward identifying various types of neuronal progenitors. Recent
technological advances in live imaging and genetic manipulation have enabled us
to link dynamic cell biological events to the molecular mechanisms that control
the asymmetric divisions of self-renewing progenitors and have provided a fresh
perspective on the modes of division of these progenitors. In addition,
comparison of progenitor repertoires between species has provided insight into
the expansion and the development of the complexity of the brain during mammalian
evolution.
|*Cell Division
[MESH]
|Animals
[MESH]
|Cell Lineage
[MESH]
|Cerebral Cortex/cytology/*growth & development
[MESH]