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10.3978/j.issn.2305-5839.2015.AB049 http://scihub22266oqcxt.onion/10.3978/j.issn.2305-5839.2015.AB049 C4563528/?report=reader!4563528!C4563528     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Transl+Med 2015 ; 3 (Suppl 2): ä Nephropedia Template TP {{tp|p=C4563528|t=2015. AB049 Aldehyde dehydrogenases: from cancer stem cells to inborn errors of metabolism |pdf=|usr=}}{{C4563528}} gab.com Text AB049 Aldehyde dehydrogenases: from cancer stem cells to inborn errors of metabolism JO: Ann Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=C4563528 #FOAvip The aldehyde dehydrogenase (ALDH) superfamily comprises NADP-dependent enzymes that catalyze the oxidation of aldehydes to their corresponding carboxylic acids. To date, 19 ALDH genes have been identified in the human genome. In addition to aldehyde metabolizing capacity, ALDHs have additional catalytic (e.g., esterase and reductase) and non-catalytic activities. The latter include functioning as structural elements in the eye (crystallins) and as binding molecules to endobioticsand xenobiotics. Mutations in human ALDH genes are the molecular basis of several diseases, including gamma-hydroxybutyricaciduria, type II hyperprolinemia, Sjögren-Larsson syndrome, pyridoxine-dependent epilepsy as well as osteoporosis and gout. ALDH enzymes also play important roles in embryogenesis and development, neurotransmission, oxidative stress and cancer. One of the most exciting recent discoveries regarding ALDHs is their identification as markers of cancer stem cells and their involvement in cancer cell resistance to chemotherapy and radiotherapy. Thus, therapeutic targeting of ALDHs may represent a novel means of more effectively treating patients with cancer or metabolic disease and improving clinical outcomes. Twit Text FOAVip AB049 Aldehyde dehydrogenases: from cancer stem cells to inborn errors of metabolism ????Ann Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=C4563528 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=C4563528 #FOAvip English Wikipedia <ref>{{Cite pmid|C4563528}}</ref> AB049 Aldehyde dehydrogenases: from cancer stem cells to inborn errors of metabolism #MMPMIDC4563528 Vasiliou V Ann Transl Med 2015[Sep]; 3 (Suppl 2): ä PMIDC4563528show ga The aldehyde dehydrogenase (ALDH) superfamily comprises NADP-dependent enzymes that catalyze the oxidation of aldehydes to their corresponding carboxylic acids. To date, 19 ALDH genes have been identified in the human genome. In addition to aldehyde metabolizing capacity, ALDHs have additional catalytic (e.g., esterase and reductase) and non-catalytic activities. The latter include functioning as structural elements in the eye (crystallins) and as binding molecules to endobioticsand xenobiotics. Mutations in human ALDH genes are the molecular basis of several diseases, including gamma-hydroxybutyricaciduria, type II hyperprolinemia, Sjögren-Larsson syndrome, pyridoxine-dependent epilepsy as well as osteoporosis and gout. ALDH enzymes also play important roles in embryogenesis and development, neurotransmission, oxidative stress and cancer. One of the most exciting recent discoveries regarding ALDHs is their identification as markers of cancer stem cells and their involvement in cancer cell resistance to chemotherapy and radiotherapy. Thus, therapeutic targeting of ALDHs may represent a novel means of more effectively treating patients with cancer or metabolic disease and improving clinical outcomes. äAB049 Aldehyde dehydrogenases: from cancer stem cells to inborn error(epmc).pdf DeepDyve Pubget Overpricing