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2015 ; 5
(9
): e008990
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The Deyo-Charlson and Elixhauser-van Walraven Comorbidity Indices as predictors
of mortality in critically ill patients
#MMPMID26351192
Ladha KS
; Zhao K
; Quraishi SA
; Kurth T
; Eikermann M
; Kaafarani HM
; Klein EN
; Seethala R
; Lee J
BMJ Open
2015[Sep]; 5
(9
): e008990
PMID26351192
show ga
OBJECTIVES: Our primary objective was to compare the utility of the Deyo-Charlson
Comorbidity Index (DCCI) and Elixhauser-van Walraven Comorbidity Index (EVCI) to
predict mortality in intensive care unit (ICU) patients. SETTING: Observational
study of 2 tertiary academic centres located in Boston, Massachusetts.
PARTICIPANTS: The study cohort consisted of 59,816 patients from admitted to 12
ICUs between January 2007 and December 2012. PRIMARY AND SECONDARY OUTCOME: For
the primary analysis, receiver operator characteristic curves were constructed
for mortality at 30, 90, 180, and 365?days using the DCCI as well as EVCI, and
the areas under the curve (AUCs) were compared. Subgroup analyses were performed
within different types of ICUs. Logistic regression was used to add age, race and
sex into the model to determine if there was any improvement in discrimination.
RESULTS: At 30?days, the AUC for DCCI versus EVCI was 0.65 (95% CI 0.65 to 0.67)
vs 0.66 (95% CI 0.65 to 0.66), p=0.02. Discrimination improved at 365?days for
both indices (AUC for DCCI 0.72 (95% CI 0.71 to 0.72) vs AUC for EVCI 0.72 (95%
CI 0.72 to 0.72), p=0.46). The DCCI and EVCI performed similarly across ICUs at
all time points, with the exception of the neurosciences ICU, where the DCCI was
superior to EVCI at all time points (1-year mortality: AUC 0.73 (95% CI 0.72 to
0.74) vs 0.68 (95% CI 0.67 to 0.70), p=0.005). The addition of basic demographic
information did not change the results at any of the assessed time points.
CONCLUSIONS: The DCCI and EVCI were comparable at predicting mortality in
critically ill patients. The predictive ability of both indices increased when
assessing long-term outcomes. Addition of demographic data to both indices did
not affect the predictive utility of these indices. Further studies are needed to
validate our findings and to determine the utility of these indices in clinical
practice.