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10.1155/2015/293524 http://scihub22266oqcxt.onion/10.1155/2015/293524 C4563088!4563088!26379708     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Virol 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26379708|t=2015. Investigation of Stilbenoids as Potential Therapeutic Agents for Rotavirus Gastroenteritis |pdf=|usr=}}{{26379708}} gab.com Text Investigation of Stilbenoids as Potential Therapeutic Agents for Rotavirus Gastroenteritis JO: Adv Virol http://www.kidney.de/pget.php?&tw=1&pmid=26379708 #FOAvip Rotavirus (RV) infections cause severe diarrhea in infants and young children worldwide. Vaccines are available but cost prohibitive for many countries and only reduce severe symptoms. Vaccinated infants continue to shed infectious particles, and studies show decreased efficacy of the RV vaccines in tropical and subtropical countries where they are needed most. Continuing surveillance for new RV strains, assessment of vaccine efficacy, and development of cost effective antiviral drugs remain an important aspect of RV studies. This study was to determine the efficacy of antioxidant and anti-inflammatory stilbenoids to inhibit RV replication. Peanut (A. hypogaea) hairy root cultures were induced to produce stilbenoids, which were purified by high performance countercurrent chromatography (HPCCC) and analyzed by HPLC. HT29.f8 cells were infected with RV in the presence stilbenoids. Cell viability counts showed no cytotoxic effects on HT29.f8 cells. Viral infectivity titers were calculated and comparatively assessed to determine the effects of stilbenoid treatments. Two stilbenoids, trans-arachidin-1 and trans-arachidin-3, show a significant decrease in RV infectivity titers. Western blot analyses performed on the infected cell lysates complemented the infectivity titrations and indicated a significant decrease in viral replication. These studies show the therapeutic potential of the stilbenoids against RV replication. Twit Text FOAVip Investigation of Stilbenoids as Potential Therapeutic Agents for Rotavirus Gastroenteritis ????Adv Virol http://www.kidney.de/pget.php?&tw=1&pmid=26379708 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26379708 #FOAvip English Wikipedia <ref>{{Cite pmid|26379708}}</ref> Investigation of Stilbenoids as Potential Therapeutic Agents for Rotavirus Gastroenteritis #MMPMID26379708 Ball JM; Medina-Bolivar F; Defrates K; Hambleton E; Hurlburt ME; Fang L; Yang T; Nopo-Olazabal L; Atwill RL; Ghai P; Parr RD Adv Virol 2015[]; 2015 (ä): ä PMID26379708show ga Rotavirus (RV) infections cause severe diarrhea in infants and young children worldwide. Vaccines are available but cost prohibitive for many countries and only reduce severe symptoms. Vaccinated infants continue to shed infectious particles, and studies show decreased efficacy of the RV vaccines in tropical and subtropical countries where they are needed most. Continuing surveillance for new RV strains, assessment of vaccine efficacy, and development of cost effective antiviral drugs remain an important aspect of RV studies. This study was to determine the efficacy of antioxidant and anti-inflammatory stilbenoids to inhibit RV replication. Peanut (A. hypogaea) hairy root cultures were induced to produce stilbenoids, which were purified by high performance countercurrent chromatography (HPCCC) and analyzed by HPLC. HT29.f8 cells were infected with RV in the presence stilbenoids. Cell viability counts showed no cytotoxic effects on HT29.f8 cells. Viral infectivity titers were calculated and comparatively assessed to determine the effects of stilbenoid treatments. Two stilbenoids, trans-arachidin-1 and trans-arachidin-3, show a significant decrease in RV infectivity titers. Western blot analyses performed on the infected cell lysates complemented the infectivity titrations and indicated a significant decrease in viral replication. These studies show the therapeutic potential of the stilbenoids against RV replication. äInvestigation of Stilbenoids as Potential Therapeutic Agents for Rotav(epmc).pdf DeepDyve Pubget Overpricing