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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Neurosci
2015 ; 9
(ä): 321
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English Wikipedia
Temporary inactivation of the anterior part of the bed nucleus of the stria
terminalis blocks alarm pheromone-induced defensive behavior in rats
#MMPMID26441496
Breitfeld T
; Bruning JE
; Inagaki H
; Takeuchi Y
; Kiyokawa Y
; Fendt M
Front Neurosci
2015[]; 9
(ä): 321
PMID26441496
show ga
Rats emit an alarm pheromone in threatening situations. Exposure of rats to this
alarm pheromone induces defensive behaviors, such as head out behavior, and
increases c-Fos expression in brain areas involved in the mediation of defensive
behaviors. One of these brain areas is the anterior bed nucleus of the stria
terminalis (aBNST). The goal of the present study was to investigate if
pharmacological inactivation of the aBNST by local microinjections of the GABAA
receptor-agonist muscimol modulates alarm pheromone-induced defensive behaviors.
We first established the behavioral paradigm of alarm pheromone-induced defensive
behaviors in Sprague-Dawley rats in our laboratory. In a second experiment, we
inactivated the aBNST, then exposed rats to one of four different odors (neck
odor, female urine, alarm pheromone, fox urine) and tested the effects of the
aBNST inactivation on the behavior in response to these odors. Our data show that
temporary inactivation of the aBNST blocked head out behavior in response to the
alarm pheromone. This indicates that the aBNST plays an important role in the
mediation of the alarm pheromone-induced defensive behavior in rats.