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2015 ; 2015
(ä): 824624
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The Prognostic Role of Red Blood Cell Distribution Width in Coronary Artery
Disease: A Review of the Pathophysiology
#MMPMID26379362
Bujak K
; Wasilewski J
; Osadnik T
; Jonczyk S
; Ko?odziejska A
; Gierlotka M
; G?sior M
Dis Markers
2015[]; 2015
(ä): 824624
PMID26379362
show ga
Red blood cell distribution width (RDW) is a measure of red blood cell volume
variations (anisocytosis) and is reported as part of a standard complete blood
count. In recent years, numerous studies have noted the importance of RDW as a
predictor of poor clinical outcomes in the settings of various diseases,
including coronary artery disease (CAD). In this paper, we discuss the prognostic
value of RDW in CAD and describe the pathophysiological connection between RDW
and acute coronary syndrome. In our opinion, the negative prognostic effects of
elevated RDW levels may be attributed to the adverse effects of independent risk
factors such as inflammation, oxidative stress, and vitamin D3 and iron
deficiency on bone marrow function (erythropoiesis). Elevated RDW values may
reflect the intensity of these phenomena and their unfavorable impacts on bone
marrow erythropoiesis. Furthermore, decreased red blood cell deformability among
patients with higher RDW values impairs blood flow through the microcirculation,
resulting in the diminution of oxygen supply at the tissue level, particularly
among patients suffering from myocardial infarction treated with urgent
revascularization.