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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Emerg+Med 2015 ; 33 (9): 1119-25 Nephropedia Template TP
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Prehospital recognition of severe sepsis: development and validation of a novel EMS screening tool #MMPMID26070235
Polito CC; Isakov A; Yancey AH; Wilson DK; Anderson BA; Bloom I; Martin GS; Sevransky JE
Am J Emerg Med 2015[Sep]; 33 (9): 1119-25 PMID26070235show ga
Objective: To derive and validate a predictive model and novel Emergency Medical Services (EMS) screening tool for severe sepsis (SS). Design: Retrospective cohort study. Setting: A single EMS system and an urban, public hospital. Patients: Sequential adult, non-trauma, non-arrest, at-risk, EMS-transported patients between January 1, 2011 and December 31, 2012. At-risk patients were defined as having all 3 of the following criteria present in the EMS setting: heart rate >90bpm, 2) respiratory rate >20bpm, and 3) systolic blood pressure <110mmHg. Interventions: None. Measurements and Main Results: Among 66,439 EMS encounters, 555 met criteria for analysis. Fourteen percent (n=75) of patients had SS, of which 19% (n=14) were identified by EMS clinical judgment. In-hospital mortality for patients with SS was 31% (n=23). Six EMS characteristics were found to be predictors of SS: older age, transport from nursing home, Emergency Medical Dispatch (EMD) 9-1-1 chief complaint category of ?Sick Person?, hot tactile temperature assessment, low systolic blood pressure, and low oxygen saturation. The final predictive model showed good discrimination in derivation and validation subgroups (AUC 0.843 and 0.820, respectively). Sensitivity of the final model was 91% in the derivation group and 78% in the validation group. At a pre-defined threshold of 2 or more points, prehospital severe sepsis (PRESS) score sensitivity was 86%. Conclusions: The PRESS score is a novel EMS screening tool for SS that demonstrates a sensitivity of 86% and specificity of 47%. Additional validation is needed before this tool can be recommended for widespread clinical use.