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10.1016/j.tips.2015.05.007

http://scihub22266oqcxt.onion/10.1016/j.tips.2015.05.007
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C4562801!4562801!26071118
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suck abstract from ncbi


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pmid26071118      Trends+Pharmacol+Sci 2015 ; 36 (9): 568-78
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  • The role of H2S bioavailability in endothelial dysfunction #MMPMID26071118
  • Wang R; Szabo C; Ichinose F; Ahmed A; Whiteman M; Papapetropoulos A
  • Trends Pharmacol Sci 2015[Sep]; 36 (9): 568-78 PMID26071118show ga
  • Endothelial dysfunction reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. Here we review the role of hydrogen sulfide (H2S) in the pathogenesis of endothelial dysfunction, one of the fastest advanced and hottest research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of the progress and prognosis of endothelial dysfunction. Endothelial dysfunction appears to exhibit in different forms in different pathologies but therapeutics aimed at remedying the altered H2S bioavailability may benefit all.
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