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10.1371/journal.pone.0137357 http://scihub22266oqcxt.onion/10.1371/journal.pone.0137357 C4562663!4562663!26348728     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (9): ä Nephropedia Template TP {{tp|p=26348728|t=2015. Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer?s Disease Pathology |pdf=|usr=}}{{26348728}} gab.com Text Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer s Disease Pathology JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26348728 #FOAvip Amyloid beta (A?) oligomers associated with Alzheimer?s disease (AD) form Ca2+-permeable plasma membrane pores, leading to a disruption of the otherwise well-controlled intracellular calcium (Ca2+) homeostasis. The resultant up-regulation of intracellular Ca2+ concentration has detrimental implications for memory formation and cell survival. The gating kinetics and Ca2+ permeability of A? pores are not well understood. We have used computational modeling in conjunction with the ability of optical patch-clamping for massively parallel imaging of Ca2+ flux through thousands of pores in the cell membrane of Xenopus oocytes to elucidate the kinetic properties of A? pores. The fluorescence time-series data from individual pores were idealized and used to develop data-driven Markov chain models for the kinetics of the A? pore at different stages of its evolution. Our study provides the first demonstration of developing Markov chain models for ion channel gating that are driven by optical-patch clamp data with the advantage of experiments being performed under close to physiological conditions. Towards the end, we demonstrate the up-regulation of gating of various Ca2+ release channels due to A? pores and show that the extent and spatial range of such up-regulation increases as A? pores with low open probability and Ca2+ permeability transition into those with high open probability and Ca2+ permeability. Twit Text FOAVip Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer s Disease Pathology ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26348728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26348728 #FOAvip English Wikipedia <ref>{{Cite pmid|26348728}}</ref> Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer?s Disease Pathology #MMPMID26348728 Ullah G; Demuro A; Parker I; Pearson JE PLoS One 2015[]; 10 (9): ä PMID26348728show ga Amyloid beta (A?) oligomers associated with Alzheimer?s disease (AD) form Ca2+-permeable plasma membrane pores, leading to a disruption of the otherwise well-controlled intracellular calcium (Ca2+) homeostasis. The resultant up-regulation of intracellular Ca2+ concentration has detrimental implications for memory formation and cell survival. The gating kinetics and Ca2+ permeability of A? pores are not well understood. We have used computational modeling in conjunction with the ability of optical patch-clamping for massively parallel imaging of Ca2+ flux through thousands of pores in the cell membrane of Xenopus oocytes to elucidate the kinetic properties of A? pores. The fluorescence time-series data from individual pores were idealized and used to develop data-driven Markov chain models for the kinetics of the A? pore at different stages of its evolution. Our study provides the first demonstration of developing Markov chain models for ion channel gating that are driven by optical-patch clamp data with the advantage of experiments being performed under close to physiological conditions. Towards the end, we demonstrate the up-regulation of gating of various Ca2+ release channels due to A? pores and show that the extent and spatial range of such up-regulation increases as A? pores with low open probability and Ca2+ permeability transition into those with high open probability and Ca2+ permeability. äAnalyzing and Modeling the Kinetics of Amyloid Beta Pores Associated w(epmc).pdf DeepDyve Pubget Overpricing