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10.1111/bph.13225 http://scihub22266oqcxt.onion/10.1111/bph.13225 C4562506!4562506!26075703     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2015 ; 172 (18): 4443-53 Nephropedia Template TP {{tp|p=26075703|t=2015. Angiotensin-(1?7) administration benefits cardiac, renal and progenitor cell function in db/db mice |pdf=|usr=}}{{26075703}} gab.com Text Angiotensin-(1 7) administration benefits cardiac, renal and progenitor cell function in db/db mice JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26075703 #FOAvip Background and Purpose: Diabetic patients are at an increased risk of cardiovascular disease, in part due to inflammation and oxidative stress. These two pathological mechanisms also affect other organs and cells including the kidneys and progenitor cells. Angiotensin-(1?7) [Ang-(1?7)] has previously been shown to counterbalance pathological effects of angiotensin II, including inflammation and oxidative stress. The aim of this study was to investigate the effects of short-term (2 weeks) Ang-(1?7) treatment on cardiovascular and renal function in a mouse model of type 2 diabetes (db/db). Experimental Approach: Eight- to nine-week-old db/db mice were administered either vehicle, Ang-(1?7) alone, or Ang-(1?7) combined with an inhibitor (losartan, PD123319, A-779, L-NAME or icatibant) daily for 14 days. Key Results: An improvement in physiological heart function was observed in Ang-(1?7)-treated mice. Ang-(1?7) also reduced cardiomyocyte hypertrophy, fibrosis and inflammatory cell infiltration of the heart tissue and increased blood vessel number. These changes were blocked by antagonists of the MAS1, AT2 and bradykinin receptors and inhibition of NO formation. Treatment with Ang-(1?7) reduced glomerular damage and oxidative stress in kidney tissue. Bone marrow and circulating endothelial progenitors, as well as bone marrow mesenchymal stem cells, were increased in mice treated with Ang-(1?7). Conclusions and Implications: Short-term Ang-(1?7) treatment of young db/db mice improved heart function and reduced kidney damage. Treatment also improved bone marrow and circulating levels of endothelial and mesenchymal stem cells. All of this may contribute to improved cardiovascular and renal function. Twit Text FOAVip Angiotensin-(1 7) administration benefits cardiac, renal and progenitor cell function in db/db mice ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26075703 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26075703 #FOAvip English Wikipedia <ref>{{Cite pmid|26075703}}</ref> Angiotensin-(1?7) administration benefits cardiac, renal and progenitor cell function in db/db mice #MMPMID26075703 Papinska AM; Mordwinkin NM; Meeks CJ; Jadhav SS; Rodgers KE Br J Pharmacol 2015[Sep]; 172 (18): 4443-53 PMID26075703show ga Background and Purpose: Diabetic patients are at an increased risk of cardiovascular disease, in part due to inflammation and oxidative stress. These two pathological mechanisms also affect other organs and cells including the kidneys and progenitor cells. Angiotensin-(1?7) [Ang-(1?7)] has previously been shown to counterbalance pathological effects of angiotensin II, including inflammation and oxidative stress. The aim of this study was to investigate the effects of short-term (2 weeks) Ang-(1?7) treatment on cardiovascular and renal function in a mouse model of type 2 diabetes (db/db). Experimental Approach: Eight- to nine-week-old db/db mice were administered either vehicle, Ang-(1?7) alone, or Ang-(1?7) combined with an inhibitor (losartan, PD123319, A-779, L-NAME or icatibant) daily for 14 days. Key Results: An improvement in physiological heart function was observed in Ang-(1?7)-treated mice. Ang-(1?7) also reduced cardiomyocyte hypertrophy, fibrosis and inflammatory cell infiltration of the heart tissue and increased blood vessel number. These changes were blocked by antagonists of the MAS1, AT2 and bradykinin receptors and inhibition of NO formation. Treatment with Ang-(1?7) reduced glomerular damage and oxidative stress in kidney tissue. Bone marrow and circulating endothelial progenitors, as well as bone marrow mesenchymal stem cells, were increased in mice treated with Ang-(1?7). Conclusions and Implications: Short-term Ang-(1?7) treatment of young db/db mice improved heart function and reduced kidney damage. Treatment also improved bone marrow and circulating levels of endothelial and mesenchymal stem cells. All of this may contribute to improved cardiovascular and renal function. äAngiotensin-(1?7) administration benefits cardiac, renal and progenito(epmc).pdf DeepDyve Pubget Overpricing