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2015 ; 2015
(ä): 517472
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English Wikipedia
Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of
Alogliptin in Patients with Type 2 Diabetes
#MMPMID26380312
Mizushige T
; Kobori H
; Nishijima Y
; Yano Y
; Sakata K
; Hayakawa M
; Nishiyama A
J Diabetes Res
2015[]; 2015
(ä): 517472
PMID26380312
show ga
BACKGROUND: The aims of this study were (1) to examine the renoprotective effects
of alogliptin and (2) to establish urinary angiotensinogen (AGT) as a prognostic
marker of renoprotective effects of alogliptin in patients with type 2 diabetes
(T2D). METHODS: In 43 patients with T2D (18 women, 66.1 ± 1.71 years), 25?mg/day
of alogliptin was added to the traditional hypoglycemic agents and/or nondrug
treatments. Urinary concentrations of albumin (Alb) and AGT, normalized by
urinary concentrations of creatinine (Cr) (UAlbCR and UAGTCR, respectively), were
measured before and after the 12-week alogliptin treatment. RESULTS: Alogliptin
treatment tended to decrease UAlbCR (99.6 ± 26.8 versus 114.6 ± 36.0?mg/g Cr, P =
0.198). Based on % change in UAlbCR, patients were divided into two groups,
responders (< -25%) and nonresponders (? -25%), and a logistic analysis of UAGTCR
before treatment showed cutoff value of 20.8?µg/g Cr. When all patients were
redivided into two groups, those with higher values of UAGTCR before the
treatment (Group H, n = 20) and those with lower values (Group L), Group H showed
significantly decreased UAlbCR in response to alogliptin (-14.6 ± 8.6 versus
+22.8 ± 16.8%, P = 0.033). CONCLUSION: Urinary AGT could be a prognostic marker
of renoprotective effects of alogliptin in patients with T2D.
|Aged
[MESH]
|Albumins/chemistry
[MESH]
|Angiotensinogen/therapeutic use/*urine
[MESH]
|Biomarkers/metabolism
[MESH]
|Creatinine/urine
[MESH]
|Diabetes Mellitus, Type 2/complications/*drug therapy/urine
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Hypoglycemic Agents/*administration & dosage/therapeutic use
[MESH]