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10.1155/2015/517472

http://scihub22266oqcxt.onion/10.1155/2015/517472
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suck abstract from ncbi


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pmid26380312
      J+Diabetes+Res 2015 ; 2015 (ä): 517472
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  • Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes #MMPMID26380312
  • Mizushige T ; Kobori H ; Nishijima Y ; Yano Y ; Sakata K ; Hayakawa M ; Nishiyama A
  • J Diabetes Res 2015[]; 2015 (ä): 517472 PMID26380312 show ga
  • BACKGROUND: The aims of this study were (1) to examine the renoprotective effects of alogliptin and (2) to establish urinary angiotensinogen (AGT) as a prognostic marker of renoprotective effects of alogliptin in patients with type 2 diabetes (T2D). METHODS: In 43 patients with T2D (18 women, 66.1 ± 1.71 years), 25?mg/day of alogliptin was added to the traditional hypoglycemic agents and/or nondrug treatments. Urinary concentrations of albumin (Alb) and AGT, normalized by urinary concentrations of creatinine (Cr) (UAlbCR and UAGTCR, respectively), were measured before and after the 12-week alogliptin treatment. RESULTS: Alogliptin treatment tended to decrease UAlbCR (99.6 ± 26.8 versus 114.6 ± 36.0?mg/g Cr, P = 0.198). Based on % change in UAlbCR, patients were divided into two groups, responders (< -25%) and nonresponders (? -25%), and a logistic analysis of UAGTCR before treatment showed cutoff value of 20.8?µg/g Cr. When all patients were redivided into two groups, those with higher values of UAGTCR before the treatment (Group H, n = 20) and those with lower values (Group L), Group H showed significantly decreased UAlbCR in response to alogliptin (-14.6 ± 8.6 versus +22.8 ± 16.8%, P = 0.033). CONCLUSION: Urinary AGT could be a prognostic marker of renoprotective effects of alogliptin in patients with T2D.
  • |Aged [MESH]
  • |Albumins/chemistry [MESH]
  • |Angiotensinogen/therapeutic use/*urine [MESH]
  • |Biomarkers/metabolism [MESH]
  • |Creatinine/urine [MESH]
  • |Diabetes Mellitus, Type 2/complications/*drug therapy/urine [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hypoglycemic Agents/*administration & dosage/therapeutic use [MESH]
  • |Japan [MESH]
  • |Kidney Diseases/complications/*urine [MESH]
  • |Kidney/drug effects [MESH]
  • |Logistic Models [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Piperidines/*administration & dosage [MESH]
  • |Prognosis [MESH]
  • |Treatment Outcome [MESH]


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