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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Asian+J+Transfus+Sci 2015 ; 9 (2): 129-32 Nephropedia Template TP
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Bombay blood group: Is prevalence decreasing with urbanization and the decreasing rate of consanguineous marriage #MMPMID26420929
Mallick S; Kotasthane DS; Chowdhury PS; Sarkar S
Asian J Transfus Sci 2015[Jul]; 9 (2): 129-32 PMID26420929show ga
Context:: Bombay blood group although rare is found to be more prevalent in the Western and Southern states of India, believed to be associated with consanguineous marriage. Aims:: To estimate the prevalence of the Bombay blood group (Oh) in the urban population of Puducherry. To find the effect of urbanization on consanguineous marriage and to establish whether consanguinity plays a part in the prevalence of Oh group. To compare Oh group prevalence with that of other neighboring states, where population is not predominantly urban. Settings and Design:: This is a descriptive study in a tertiary care hospital in Puducherry, over a period of 6 years. Materials and Methods:: All blood samples showing ?O? group were tested with anti-H lectin. Specialized tests like Adsorption Elution Technique, inhibition assay for determination of secretor status were performed on Oh positive cases. Any history of consanguineous marriage was recorded. Statistical Analysis Used:: All variables were categorical variable and percentage and proportions were calculated manually. Results:: Analysis of the results of 35,497 study subjects showed that the most common group was ?O? group constituting 14,164 (39.90%) of subjects. Only three ?Oh? that is, Bombay phenotype (0.008%) were detected. Consanguinity was observed in two cases (66.66%). Conclusions:: This study shows the prevalence of Bombay blood group representing the urban population of Puducherry, to be high (0.008%) and associated with consanguineous marriage (66.66%). Thus, consanguinity is still an important risk factor present, even in an urban population in Southern India.