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10.3389/fmed.2015.00064 http://scihub22266oqcxt.onion/10.3389/fmed.2015.00064 C4561802!4561802!26442266     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Med+(Lausanne) 2015 ; 2 (ä): ä Nephropedia Template TP {{tp|p=26442266|t=2015. Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer |pdf=|usr=}}{{26442266}} gab.com Text Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer JO: Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=26442266 #FOAvip Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGF? signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the cluster?s oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer. Twit Text FOAVip Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer ????Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=26442266 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26442266 #FOAvip English Wikipedia <ref>{{Cite pmid|26442266}}</ref> Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer #MMPMID26442266 Fuziwara CS; Kimura ET Front Med (Lausanne) 2015[]; 2 (ä): ä PMID26442266show ga Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGF? signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the cluster?s oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer. äInsights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer (epmc).pdf DeepDyve Pubget Overpricing