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10.1101/cshperspect.a023085

http://scihub22266oqcxt.onion/10.1101/cshperspect.a023085
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suck abstract from ncbi


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pmid26187875
      Cold+Spring+Harb+Perspect+Med 2015 ; 5 (9 ): a023085
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  • Noninvasive Prenatal Screening for Genetic Diseases Using Massively Parallel Sequencing of Maternal Plasma DNA #MMPMID26187875
  • Chitty LS ; Lo YM
  • Cold Spring Harb Perspect Med 2015[Jul]; 5 (9 ): a023085 PMID26187875 show ga
  • The identification of cell-free fetal DNA (cffDNA) in maternal plasma in 1997 heralded the most significant change in obstetric care for decades, with the advent of safer screening and diagnosis based on analysis of maternal blood. Here, we describe how the technological advances offered by next-generation sequencing have allowed for the development of a highly sensitive screening test for aneuploidies as well as definitive prenatal molecular diagnosis for some monogenic disorders.
  • |Aneuploidy [MESH]
  • |Attitude of Health Personnel [MESH]
  • |Attitude to Health [MESH]
  • |Cell-Free System [MESH]
  • |DNA Methylation/physiology [MESH]
  • |DNA/blood/*genetics [MESH]
  • |Female [MESH]
  • |Gene Expression Profiling/economics [MESH]
  • |Genetic Diseases, Inborn/*diagnosis/economics [MESH]
  • |Genetic Testing [MESH]
  • |Humans [MESH]
  • |Intellectual Property [MESH]
  • |Plasma [MESH]
  • |Pregnancy [MESH]
  • |Prenatal Diagnosis/economics/*methods [MESH]


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