Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.1500792 http://scihub22266oqcxt.onion/10.4049/jimmunol.1500792 C4561209!4561209!26268653     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 195 (6): 2571-9 Nephropedia Template TP {{tp|p=26268653|t=2015. B Cell-Specific MHC Class II Deletion Reveals Multiple Non-Redundant Roles for B Cell Antigen Presentation in Murine Lupus1 |pdf=|usr=}}{{26268653}} gab.com Text B Cell-Specific MHC Class II Deletion Reveals Multiple Non-Redundant Roles for B Cell Antigen Presentation in Murine Lupus1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26268653 #FOAvip B cells have both antibody-dependent and antibody-independent functions in systemic autoimmune diseases, including systemic lupus erythematosus (SLE). Antibody-independent functions are known to be important, since mice with B cells but no secreted immunoglobulin have severe disease. These functions could include roles in lymphoid development, cytokine secretion, and antigen presentation; however, these possibilities have not been directly tested in SLE models. Here we show by lineage-specific ablation of MHC class II (MHCII) that B cell antigen presentation plays a non-redundant role in CD4+ T cell activation and effector differentiation in the MRL.Faslpr mouse model of SLE. MHCII-mediated interactions between B cells and T cells further promote B cell proliferation and differentiation and, in fact, inefficient MHCII deletion on B cells led to strong selection of ?escaped? cells in activated and plasmablast compartments, further underscoring the central role of B cell antigen presentation. Despite the ?leakiness? in the system, B cell-specific MHCII deletion resulted in substantially ameliorated clinical disease. Hence, B cell antigen presentation is critical for T and B cell activation and differentiation, as well as target organ damage. Twit Text FOAVip B Cell-Specific MHC Class II Deletion Reveals Multiple Non-Redundant Roles for B Cell Antigen Presentation in Murine Lupus1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26268653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26268653 #FOAvip English Wikipedia <ref>{{Cite pmid|26268653}}</ref> B Cell-Specific MHC Class II Deletion Reveals Multiple Non-Redundant Roles for B Cell Antigen Presentation in Murine Lupus1 #MMPMID26268653 Giles JR; Kashgarian M; Koni PA; Shlomchik MJ J Immunol 2015[Sep]; 195 (6): 2571-9 PMID26268653show ga B cells have both antibody-dependent and antibody-independent functions in systemic autoimmune diseases, including systemic lupus erythematosus (SLE). Antibody-independent functions are known to be important, since mice with B cells but no secreted immunoglobulin have severe disease. These functions could include roles in lymphoid development, cytokine secretion, and antigen presentation; however, these possibilities have not been directly tested in SLE models. Here we show by lineage-specific ablation of MHC class II (MHCII) that B cell antigen presentation plays a non-redundant role in CD4+ T cell activation and effector differentiation in the MRL.Faslpr mouse model of SLE. MHCII-mediated interactions between B cells and T cells further promote B cell proliferation and differentiation and, in fact, inefficient MHCII deletion on B cells led to strong selection of ?escaped? cells in activated and plasmablast compartments, further underscoring the central role of B cell antigen presentation. Despite the ?leakiness? in the system, B cell-specific MHCII deletion resulted in substantially ameliorated clinical disease. Hence, B cell antigen presentation is critical for T and B cell activation and differentiation, as well as target organ damage. äB Cell-Specific MHC Class II Deletion Reveals Multiple Non-Redundant R(epmc).pdf DeepDyve Pubget Overpricing