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10.4049/jimmunol.1500792 http://scihub22266oqcxt.onion/10.4049/jimmunol.1500792 C4561209!4561209 !26268653     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26268653 &cmd=llinks): Failed to open stream: HTTP request failed! 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B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus |pdf=|usr=}}{{26268653 }} gab.com Text B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26268653 #FOAvip B cells have both Ab-dependent and Ab-independent functions in systemic autoimmune diseases, including systemic lupus erythematosus (SLE). Ab-independent functions are known to be important, because mice with B cells but no secreted Ig have severe disease. These functions could include roles in lymphoid development, cytokine secretion, and Ag presentation; however, these possibilities have not been directly tested in SLE models. In this study, we show by lineage-specific ablation of MHC class II (MHCII) that B cell Ag presentation plays a nonredundant role in CD4(+) T cell activation and effector differentiation in the MRL.Fas(lpr) mouse model of SLE. MHCII-mediated interactions between B and T cells further promote B cell proliferation and differentiation, and, in fact, inefficient MHCII deletion on B cells led to strong selection of escaped cells in activated and plasmablast compartments, further underscoring the central role of B cell Ag presentation. Despite the leakiness in the system, B cell-specific MHCII deletion resulted in substantially ameliorated clinical disease. Hence, B cell Ag presentation is critical for T and B cell activation and differentiation, as well as target organ damage. Twit Text FOAVip B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26268653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26268653 #FOAvip English Wikipedia <ref>{{Cite pmid|26268653 }}</ref> B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus #MMPMID26268653 Giles JR ; Kashgarian M ; Koni PA ; Shlomchik MJ J Immunol 2015[Sep]; 195 (6 ): 2571-9 PMID26268653 show ga B cells have both Ab-dependent and Ab-independent functions in systemic autoimmune diseases, including systemic lupus erythematosus (SLE). Ab-independent functions are known to be important, because mice with B cells but no secreted Ig have severe disease. These functions could include roles in lymphoid development, cytokine secretion, and Ag presentation; however, these possibilities have not been directly tested in SLE models. In this study, we show by lineage-specific ablation of MHC class II (MHCII) that B cell Ag presentation plays a nonredundant role in CD4(+) T cell activation and effector differentiation in the MRL.Fas(lpr) mouse model of SLE. MHCII-mediated interactions between B and T cells further promote B cell proliferation and differentiation, and, in fact, inefficient MHCII deletion on B cells led to strong selection of escaped cells in activated and plasmablast compartments, further underscoring the central role of B cell Ag presentation. Despite the leakiness in the system, B cell-specific MHCII deletion resulted in substantially ameliorated clinical disease. Hence, B cell Ag presentation is critical for T and B cell activation and differentiation, as well as target organ damage. |Animals [MESH] |Antigen Presentation/*immunology [MESH] |Autoantibodies/immunology [MESH] |B-Lymphocytes/*immunology [MESH] |CD4-Positive T-Lymphocytes/cytology/immunology [MESH] |Cell Differentiation/immunology [MESH] |Cell Proliferation/genetics [MESH] |Cytokines/metabolism [MESH] |Genes, MHC Class II/genetics/*immunology [MESH] |Histocompatibility Antigens Class II/*genetics/immunology [MESH] |Lupus Erythematosus, Systemic/*immunology [MESH] |Lupus Nephritis/immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Mice [MESH]B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Ro(epmc).pdf DeepDyve Pubget Overpricing