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10.4049/jimmunol.1500957 http://scihub22266oqcxt.onion/10.4049/jimmunol.1500957 C4561202!4561202!26268654     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 195 (6): 2666-74 Nephropedia Template TP {{tp|p=26268654|t=2015. Inhibition of B-lymphopoiesis by Adipocytes and IL-1-producing MDSCs1 |pdf=|usr=}}{{26268654}} gab.com Text Inhibition of B-lymphopoiesis by Adipocytes and IL-1-producing MDSCs1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26268654 #FOAvip B-lymphopoiesis declines with age, and this decline not only correlates with increased adipose tissue in the bone marrow (BM), but also adipocyte-derived factors are known to inhibit B-lymphopoiesis. Using co-cultures of mouse BM cells with OP9 stromal cells, we found that adipocyte-conditioned medium (ACM) induces the generation of CD11b+Gr1+ myeloid cells which inhibit B-cell development in vitro. ACM-induced CD11b+Gr1+ cells express Arg1 (arginase) and Nos2 (iNos), and suppress CD4+ T-cell proliferation, indicating that these cells are myeloid-derived suppressor cells (MDSCs). Blocking arginase and iNos did not restore B-lymphopoiesis, indicating that inhibition is not mediated by these molecules. Transwell and conditioned-medium experiments showed that MDSCs inhibit B-lymphopoiesis via soluble factors, and by cytokine array we identified IL-1 as an important factor. Addition of anti-IL-1 antibodies restored B-lymphopoiesis in BM cultures containing MDSCs, showing that MDSC inhibition of B-lymphopoiesis is mediated by IL-1. By treating hematopoietic precursors with IL-1, we found that multipotent progenitors (MPP) are targets of IL-1. This study uncovers a novel function for MDSCs to inhibit B-lymphopoiesis through IL-1. We suggest that inflammaging contributes to a decline of B-lymphopoiesis in aged individuals, and further, that MDSCs and IL-1 provide therapeutic targets for restoration of B-lymphopoiesis in aged and obese individuals. Twit Text FOAVip Inhibition of B-lymphopoiesis by Adipocytes and IL-1-producing MDSCs1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26268654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26268654 #FOAvip English Wikipedia <ref>{{Cite pmid|26268654}}</ref> Inhibition of B-lymphopoiesis by Adipocytes and IL-1-producing MDSCs1 #MMPMID26268654 Kennedy DE; Knight KL J Immunol 2015[Sep]; 195 (6): 2666-74 PMID26268654show ga B-lymphopoiesis declines with age, and this decline not only correlates with increased adipose tissue in the bone marrow (BM), but also adipocyte-derived factors are known to inhibit B-lymphopoiesis. Using co-cultures of mouse BM cells with OP9 stromal cells, we found that adipocyte-conditioned medium (ACM) induces the generation of CD11b+Gr1+ myeloid cells which inhibit B-cell development in vitro. ACM-induced CD11b+Gr1+ cells express Arg1 (arginase) and Nos2 (iNos), and suppress CD4+ T-cell proliferation, indicating that these cells are myeloid-derived suppressor cells (MDSCs). Blocking arginase and iNos did not restore B-lymphopoiesis, indicating that inhibition is not mediated by these molecules. Transwell and conditioned-medium experiments showed that MDSCs inhibit B-lymphopoiesis via soluble factors, and by cytokine array we identified IL-1 as an important factor. Addition of anti-IL-1 antibodies restored B-lymphopoiesis in BM cultures containing MDSCs, showing that MDSC inhibition of B-lymphopoiesis is mediated by IL-1. By treating hematopoietic precursors with IL-1, we found that multipotent progenitors (MPP) are targets of IL-1. This study uncovers a novel function for MDSCs to inhibit B-lymphopoiesis through IL-1. We suggest that inflammaging contributes to a decline of B-lymphopoiesis in aged individuals, and further, that MDSCs and IL-1 provide therapeutic targets for restoration of B-lymphopoiesis in aged and obese individuals. äInhibition of B-lymphopoiesis by Adipocytes and IL-1-producing MDSCs1 (epmc).pdf DeepDyve Pubget Overpricing