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10.1016/j.febslet.2015.02.028 http://scihub22266oqcxt.onion/10.1016/j.febslet.2015.02.028 C4561042!4561042!25749369     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Lett 2015 ; 589 (19 0 0): 2627-39 Nephropedia Template TP {{tp|p=25749369|t=2015. Structural Stability and Functional Remodeling of High-Density Lipoproteins |pdf=|usr=}}{{25749369}} gab.com Text Structural Stability and Functional Remodeling of High-Density Lipoproteins JO: FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=25749369 #FOAvip Lipoproteins are protein-lipid nanoparticles that transport lipids in circulation and are central in atherosclerosis and other disorders of lipid metabolism. Apolipoproteins form flexible structural scaffolds and important functional ligands on the particle surface and direct lipoprotein metabolism. Lipoproteins undergo multiple rounds of metabolic remodeling that is crucial to lipid transport. Important aspects of this remodeling, including apolipoprotein dissociation and particle fusion, are mimicked in thermal or chemical denaturation and are modulated by free energy barriers. Here we review our biophysical studies that revealed kinetic mechanism of lipoprotein stabilization and unraveled its structural basis. The main focus is on high-density lipoprotein (HDL). An inverse correlation between stability and functions of various HDLs in cholesterol transport suggests functional role of structural disorder. A mechanism for conformational adaptation of the major HDL proteins, apoA-I and apoA-II, to the increasing lipid load is proposed. Together, these studies help understand why HDL form discrete subclasses separated by kinetic barriers, which have distinct composition, conformation and functional properties. Understanding these properties may help improve HDL quality and develop novel therapies for cardiovascular disease. Twit Text FOAVip Structural Stability and Functional Remodeling of High-Density Lipoproteins ????FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=25749369 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25749369 #FOAvip English Wikipedia <ref>{{Cite pmid|25749369}}</ref> Structural Stability and Functional Remodeling of High-Density Lipoproteins #MMPMID25749369 Gursky O FEBS Lett 2015[Sep]; 589 (19 0 0): 2627-39 PMID25749369show ga Lipoproteins are protein-lipid nanoparticles that transport lipids in circulation and are central in atherosclerosis and other disorders of lipid metabolism. Apolipoproteins form flexible structural scaffolds and important functional ligands on the particle surface and direct lipoprotein metabolism. Lipoproteins undergo multiple rounds of metabolic remodeling that is crucial to lipid transport. Important aspects of this remodeling, including apolipoprotein dissociation and particle fusion, are mimicked in thermal or chemical denaturation and are modulated by free energy barriers. Here we review our biophysical studies that revealed kinetic mechanism of lipoprotein stabilization and unraveled its structural basis. The main focus is on high-density lipoprotein (HDL). An inverse correlation between stability and functions of various HDLs in cholesterol transport suggests functional role of structural disorder. A mechanism for conformational adaptation of the major HDL proteins, apoA-I and apoA-II, to the increasing lipid load is proposed. Together, these studies help understand why HDL form discrete subclasses separated by kinetic barriers, which have distinct composition, conformation and functional properties. Understanding these properties may help improve HDL quality and develop novel therapies for cardiovascular disease. äStructural Stability and Functional Remodeling of High-Density Lipopro(epmc).pdf DeepDyve Pubget Overpricing