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10.1016/j.molcel.2015.07.007 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.07.007 C4560999!4560999!26257282     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2015 ; 59 (5): 755-67 Nephropedia Template TP {{tp|p=26257282|t=2015. Interaction between TBP and condensin drives the organization and faithful segregation of mitotic chromosomes |pdf=|usr=}}{{26257282}} gab.com Text Interaction between TBP and condensin drives the organization and faithful segregation of mitotic chromosomes JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26257282 #FOAvip Genome/chromosome organization is highly ordered and controls various nuclear events, although the molecular mechanisms underlying the functional organization remain largely unknown. Here, we show that the TATA box-binding protein (TBP) interacts with the Cnd2 kleisin subunit of condensin to mediate interphase and mitotic chromosomal organization in fission yeast. TBP recruits condensin onto RNA polymerase III-transcribed (Pol III) genes and highly transcribed Pol II genes; condensin in turn associates these genes with centromeres. Inhibition of the Cnd2-TBP interaction disrupts condensin localization across the genome and the proper assembly of mitotic chromosomes, leading to severe defects in chromosome segregation and eventually causing cellular lethality. We propose that the Cnd2-TBP interaction coordinates transcription with chromosomal architecture by linking dispersed gene loci with centromeres. This chromosome arrangement can contribute to the efficient transmission of physical force at the kinetochore to chromosomal arms, thereby supporting the fidelity of chromosome segregation. Twit Text FOAVip Interaction between TBP and condensin drives the organization and faithful segregation of mitotic chromosomes ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26257282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26257282 #FOAvip English Wikipedia <ref>{{Cite pmid|26257282}}</ref> Interaction between TBP and condensin drives the organization and faithful segregation of mitotic chromosomes #MMPMID26257282 Iwasaki O; Tanizawa H; Kim KD; Yokoyama Y; Corcoran CJ; Tanaka A; Skordalakes E; Showe LC; Noma Ki Mol Cell 2015[Sep]; 59 (5): 755-67 PMID26257282show ga Genome/chromosome organization is highly ordered and controls various nuclear events, although the molecular mechanisms underlying the functional organization remain largely unknown. Here, we show that the TATA box-binding protein (TBP) interacts with the Cnd2 kleisin subunit of condensin to mediate interphase and mitotic chromosomal organization in fission yeast. TBP recruits condensin onto RNA polymerase III-transcribed (Pol III) genes and highly transcribed Pol II genes; condensin in turn associates these genes with centromeres. Inhibition of the Cnd2-TBP interaction disrupts condensin localization across the genome and the proper assembly of mitotic chromosomes, leading to severe defects in chromosome segregation and eventually causing cellular lethality. We propose that the Cnd2-TBP interaction coordinates transcription with chromosomal architecture by linking dispersed gene loci with centromeres. This chromosome arrangement can contribute to the efficient transmission of physical force at the kinetochore to chromosomal arms, thereby supporting the fidelity of chromosome segregation. äInteraction between TBP and condensin drives the organization and fait(epmc).pdf DeepDyve Pubget Overpricing