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10.1016/j.molcel.2015.07.016 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.07.016 C4560838!4560838!26340423     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26340423&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2015 ; 59 (5): 794-806 Nephropedia Template TP {{tp|p=26340423|t=2015. Architecture of the human and yeast general transcription and DNA repair factor TFIIH |pdf=|usr=}}{{26340423}} gab.com Text Architecture of the human and yeast general transcription and DNA repair factor TFIIH JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26340423 #FOAvip TFIIH is essential for both RNA polymerase II transcription and DNA repair, and mutations in TFIIH can result in human disease. Here, we determine the molecular architecture of human and yeast TFIIH by an integrative approach using chemical crosslinking/mass spectrometry (CXMS) data, biochemical analyses, and previously published electron microscopy maps. We identified four new conserved ?topological regions? that function as hubs for TFIIH assembly and more than 35 conserved topological features within TFIIH, illuminating a network of interactions involved in TFIIH assembly and regulation of its activities. We show that one of these conserved regions, the p62/Tfb1 Anchor region, directly interacts with the DNA helicase subunit XPD/Rad3 in native TFIIH and is required for the integrity and function of TFIIH. We also reveal the structural basis for defects in patients with Xeroderma pigmentosum and Trichothiodystrophy, with mutations found at the interface between the p62 Anchor region and the XPD subunit. Twit Text FOAVip Architecture of the human and yeast general transcription and DNA repair factor TFIIH ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26340423 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26340423 #FOAvip English Wikipedia <ref>{{Cite pmid|26340423}}</ref> Architecture of the human and yeast general transcription and DNA repair factor TFIIH #MMPMID26340423 Luo J; Cimermancic P; Viswanath S; Ebmeier CC; Kim B; Dehecq M; Raman V; Greenberg CH; Pellarin R; Sali A; Taatjes DJ; Hahn S; Ranish J Mol Cell 2015[Sep]; 59 (5): 794-806 PMID26340423show ga TFIIH is essential for both RNA polymerase II transcription and DNA repair, and mutations in TFIIH can result in human disease. Here, we determine the molecular architecture of human and yeast TFIIH by an integrative approach using chemical crosslinking/mass spectrometry (CXMS) data, biochemical analyses, and previously published electron microscopy maps. We identified four new conserved ?topological regions? that function as hubs for TFIIH assembly and more than 35 conserved topological features within TFIIH, illuminating a network of interactions involved in TFIIH assembly and regulation of its activities. We show that one of these conserved regions, the p62/Tfb1 Anchor region, directly interacts with the DNA helicase subunit XPD/Rad3 in native TFIIH and is required for the integrity and function of TFIIH. We also reveal the structural basis for defects in patients with Xeroderma pigmentosum and Trichothiodystrophy, with mutations found at the interface between the p62 Anchor region and the XPD subunit. äArchitecture of the human and yeast general transcription and DNA repa(epmc).pdf DeepDyve Pubget Overpricing