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10.1038/ncomms9078 http://scihub22266oqcxt.onion/10.1038/ncomms9078 C4560804!4560804!26307671     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26307671|t=2015. Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1 |pdf=|usr=}}{{26307671}} gab.com Text Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26307671 #FOAvip Humans resist infection by the African parasite Trypanosoma brucei owing to the trypanolytic activity of the serum apolipoprotein L1 (APOL1). Following uptake by endocytosis in the parasite, APOL1 forms pores in endolysosomal membranes and triggers lysosome swelling. Here we show that APOL1 induces both lysosomal and mitochondrial membrane permeabilization (LMP and MMP). Trypanolysis coincides with MMP and consecutive release of the mitochondrial TbEndoG endonuclease to the nucleus. APOL1 is associated with the kinesin TbKIFC1, of which both the motor and vesicular trafficking VHS domains are required for MMP, but not for LMP. The presence of APOL1 in the mitochondrion is accompanied by mitochondrial membrane fenestration, which can be mimicked by knockdown of a mitochondrial mitofusin-like protein (TbMFNL). The BH3-like peptide of APOL1 is required for LMP, MMP and trypanolysis. Thus, trypanolysis by APOL1 is linked to apoptosis-like MMP occurring together with TbKIFC1-mediated transport of APOL1 from endolysosomal membranes to the mitochondrion. Twit Text FOAVip Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26307671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26307671 #FOAvip English Wikipedia <ref>{{Cite pmid|26307671}}</ref> Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1 #MMPMID26307671 Vanwalleghem G; Fontaine F; Lecordier L; Tebabi P; Klewe K; Nolan DP; Yamaryo-Botté Y; Botté C; Kremer A; Burkard GS; Rassow J; Roditi I; Pérez-Morga D; Pays E Nat Commun 2015[]; 6 (ä): ä PMID26307671show ga Humans resist infection by the African parasite Trypanosoma brucei owing to the trypanolytic activity of the serum apolipoprotein L1 (APOL1). Following uptake by endocytosis in the parasite, APOL1 forms pores in endolysosomal membranes and triggers lysosome swelling. Here we show that APOL1 induces both lysosomal and mitochondrial membrane permeabilization (LMP and MMP). Trypanolysis coincides with MMP and consecutive release of the mitochondrial TbEndoG endonuclease to the nucleus. APOL1 is associated with the kinesin TbKIFC1, of which both the motor and vesicular trafficking VHS domains are required for MMP, but not for LMP. The presence of APOL1 in the mitochondrion is accompanied by mitochondrial membrane fenestration, which can be mimicked by knockdown of a mitochondrial mitofusin-like protein (TbMFNL). The BH3-like peptide of APOL1 is required for LMP, MMP and trypanolysis. Thus, trypanolysis by APOL1 is linked to apoptosis-like MMP occurring together with TbKIFC1-mediated transport of APOL1 from endolysosomal membranes to the mitochondrion. äCoupling of lysosomal and mitochondrial membrane permeabilization in t(epmc).pdf DeepDyve Pubget Overpricing