Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nsmb.3064 http://scihub22266oqcxt.onion/10.1038/nsmb.3064 C4560639!4560639!26237511     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Struct+Mol+Biol 2015 ; 22 (9): 672-8 Nephropedia Template TP {{tp|p=26237511|t=2015. The Tuberculosis Necrotizing Toxin kills macrophages by hydrolyzing NAD |pdf=|usr=}}{{26237511}} gab.com Text The Tuberculosis Necrotizing Toxin kills macrophages by hydrolyzing NAD JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26237511 #FOAvip Mycobacterium tuberculosis (Mtb) induces necrosis of infected cells to evade immune responses. Recently, we found that Mtb utilizes the protein CpnT to kill human macrophages by secreting its C-terminal domain, named tuberculosis necrotizing toxin (TNT) that induces necrosis by an unknown mechanism. Here we show that TNT gains access to the cytosol of Mtb-infected macrophages, where it hydrolyzes the essential co-enzyme nicotinamide adenine dinucleotide (NAD+). Expression or injection of a non-catalytic TNT mutant showed no cytotoxicity in macrophages or zebrafish zygotes, respectively, demonstrating that the NAD+-glycohydrolase activity is required for TNT-induced cell death. To prevent self-poisoning, Mtb produces an immunity factor for TNT (IFT) that binds TNT and inhibits its activity. The crystal structure of the TNT-IFT complex revealed a novel NAD+-glycohydrolase fold of TNT, which constitutes the founding member of a toxin family wide-spread in pathogenic microorganisms. Twit Text FOAVip The Tuberculosis Necrotizing Toxin kills macrophages by hydrolyzing NAD ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26237511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26237511 #FOAvip English Wikipedia <ref>{{Cite pmid|26237511}}</ref> The Tuberculosis Necrotizing Toxin kills macrophages by hydrolyzing NAD #MMPMID26237511 Sun J; Siroy A; Lokareddy RK; Speer A; Doornbos KS; Cingolani G; Niederweis M Nat Struct Mol Biol 2015[Sep]; 22 (9): 672-8 PMID26237511show ga Mycobacterium tuberculosis (Mtb) induces necrosis of infected cells to evade immune responses. Recently, we found that Mtb utilizes the protein CpnT to kill human macrophages by secreting its C-terminal domain, named tuberculosis necrotizing toxin (TNT) that induces necrosis by an unknown mechanism. Here we show that TNT gains access to the cytosol of Mtb-infected macrophages, where it hydrolyzes the essential co-enzyme nicotinamide adenine dinucleotide (NAD+). Expression or injection of a non-catalytic TNT mutant showed no cytotoxicity in macrophages or zebrafish zygotes, respectively, demonstrating that the NAD+-glycohydrolase activity is required for TNT-induced cell death. To prevent self-poisoning, Mtb produces an immunity factor for TNT (IFT) that binds TNT and inhibits its activity. The crystal structure of the TNT-IFT complex revealed a novel NAD+-glycohydrolase fold of TNT, which constitutes the founding member of a toxin family wide-spread in pathogenic microorganisms. äThe Tuberculosis Necrotizing Toxin kills macrophages by hydrolyzing NA(epmc).pdf DeepDyve Pubget Overpricing