Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26337959
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26337959
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Exp+Clin+Cancer+Res
2015 ; 34
(1
): 94
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer
cell growth in vitro and in vivo
#MMPMID26337959
Xun C
; Chen MB
; Qi L
; Tie-Ning Z
; Peng X
; Ning L
; Zhi-Xiao C
; Li-Wei W
J Exp Clin Cancer Res
2015[Sep]; 34
(1
): 94
PMID26337959
show ga
BACKGROUND: Colorectal cancer (CRC) is a major health problem in China and around
the world. It is one of the leading causes of cancer-related deaths. Research
groups are thus searching for novel and more efficient anti-CRC agents. RESULTS:
Here we demonstrated that ABC294640, a novel SphK2 inhibitor, induced growth
inhibition and apoptosis in transformed and primary CRC cells. The SphK activity
was remarkably inhibited by ABC294640, accompanied by sphingosine-1-phosphate
(S1P) depletion and ceramide incensement in CRC cells. Exogenously-added S1P
inhibited ABC294640-induced HT-29 cell lethality. While C6 ceramide and SphK1
inhibitor SKI-II facilitated ABC294640-induced cytotoxicity against HT-29 cells.
ABC294640 inhibited AKT-S6K1, but activated JNK signaling in transformed and
primary CRC cells. JNK inhibitors (SP600125 and JNKi-II) alleviated
ABC294640-induced CRC cell apoptosis. Moreover, a low concentration of ABC294640
sensitized the activity of 5-FU and cisplatin in vitro. In vivo, ABC294640 oral
administration dramatically inhibited HT-29 xenografts growth in nude mice.
CONCLUSIONS: Targeting of SphK2 by ABC294640 potently inhibits CRC cell growth
both in vitro and in vivo, ABC294640 could be developed as a novel therapeutic
for the treatment of CRC.
free
free
free
