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10.1371/journal.pone.0137486 http://scihub22266oqcxt.onion/10.1371/journal.pone.0137486 C4559424!4559424 !26334633     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 328.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 328.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 328.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26334633 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (9 ): e0137486 Nephropedia Template TP {{tp|p=26334633 |t=2015. Enhanced Expression of Integrin ?v?3 Induced by TGF-? Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-?-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells |pdf=|usr=}}{{26334633 }} gab.com Text Enhanced Expression of Integrin v 3 Induced by TGF- Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF- -Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26334633 #FOAvip Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor ? (TGF-?) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However, the role of growth factors in EMT has not been fully established. Several integrins are upregulated by TGF-?1 during EMT. Integrins are involved in growth factor signaling through integrin-growth factor receptor crosstalk. We previously reported that FGF1 directly binds to integrin ?v?3 and the interaction was required for FGF1 functions such as cell proliferation and migration. We studied the role of ?v?3 induced by TGF-? on TGF-?-induced EMT. Here, we describe that FGF1 augmented EMT induced by TGF-?1 in MCF10A and MCF12A mammary epithelial cells. TGF-?1 markedly amplified integrin ?v?3 and FGFR1 (but not FGFR2). We studied if the enhancing effect of FGF1 on TGF-?1-induced EMT requires enhanced levels of both integrin ?v?3 expression and FGFR1. Knockdown of ?3 suppressed the enhancement by FGF1 of TGF-?1-induced EMT in MCF10A cells. Antagonists to FGFR suppressed the enhancing effect of FGF1 on EMT. Integrin-binding defective FGF1 mutant did not augment TGF-?1-induced EMT in MCF10A cells. These findings suggest that enhanced integrin ?v?3 expression in addition to enhanced FGFR1 expression is critical for FGF1 to augment TGF-?1-induced EMT in mammary epithelial cells. Twit Text FOAVip Enhanced Expression of Integrin v 3 Induced by TGF- Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF- -Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26334633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26334633 #FOAvip English Wikipedia <ref>{{Cite pmid|26334633 }}</ref> Enhanced Expression of Integrin ?v?3 Induced by TGF-? Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-?-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells #MMPMID26334633 Mori S ; Kodaira M ; Ito A ; Okazaki M ; Kawaguchi N ; Hamada Y ; Takada Y ; Matsuura N PLoS One 2015[]; 10 (9 ): e0137486 PMID26334633 show ga Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor ? (TGF-?) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However, the role of growth factors in EMT has not been fully established. Several integrins are upregulated by TGF-?1 during EMT. Integrins are involved in growth factor signaling through integrin-growth factor receptor crosstalk. We previously reported that FGF1 directly binds to integrin ?v?3 and the interaction was required for FGF1 functions such as cell proliferation and migration. We studied the role of ?v?3 induced by TGF-? on TGF-?-induced EMT. Here, we describe that FGF1 augmented EMT induced by TGF-?1 in MCF10A and MCF12A mammary epithelial cells. TGF-?1 markedly amplified integrin ?v?3 and FGFR1 (but not FGFR2). We studied if the enhancing effect of FGF1 on TGF-?1-induced EMT requires enhanced levels of both integrin ?v?3 expression and FGFR1. Knockdown of ?3 suppressed the enhancement by FGF1 of TGF-?1-induced EMT in MCF10A cells. Antagonists to FGFR suppressed the enhancing effect of FGF1 on EMT. Integrin-binding defective FGF1 mutant did not augment TGF-?1-induced EMT in MCF10A cells. These findings suggest that enhanced integrin ?v?3 expression in addition to enhanced FGFR1 expression is critical for FGF1 to augment TGF-?1-induced EMT in mammary epithelial cells. |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Epithelial Cells/*drug effects/metabolism [MESH] |Epithelial-Mesenchymal Transition/*drug effects/physiology [MESH] |Fibroblast Growth Factor 1/*pharmacology [MESH] |Humans [MESH] |Integrin alphaVbeta3/*metabolism [MESH] |Mammary Glands, Human/drug effects/metabolism/pathology [MESH] |Receptor, Fibroblast Growth Factor, Type 1/metabolism [MESH] |Signal Transduction/drug effects [MESH]Enhanced Expression of Integrin ?v?3 Induced by TGF-? Is Required for (epmc).pdf DeepDyve Pubget Overpricing