Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12974-015-0373-x http://scihub22266oqcxt.onion/10.1186/s12974-015-0373-x C4559066!4559066 !26337552     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26337552 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Neuroinflammation 2015 ; 12 (ä): 155 Nephropedia Template TP {{tp|p=26337552 |t=2015. Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury |pdf=|usr=}}{{26337552 }} gab.com Text Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury JO: J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=26337552 #FOAvip BACKGROUND: Neuroendoscopy is an innovative technique for neurosurgery that can nonetheless result in traumatic brain injury. The accompanying neuroinflammation may lead to secondary tissue damage, which is the major cause of delayed neuronal death after surgery. The present study investigated the capacity of osthole to prevent secondary brain injury and the underlying mechanism of action in a mouse model of stab wound injury. METHODS: A mouse model of cortical stab wound injury was established by inserting a needle into the cerebral cortex for 20 min to mimic neuroendoscopy. Mice received an intraperitoneal injection of osthole 30 min after surgery and continued for 14 days. Neurological severity was evaluated 12 h and up to 21 days after the trauma. Brains were collected 3-21 days post-injury for histological analysis, immunocytochemistry, quantitative real-time PCR, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and enzyme-linked immunosorbent assays. RESULTS: Neurological function improved in mice treated with osthole and was accompanied by reduced brain water content and accelerated wound closure relative to untreated mice. Osthole treatment reduced the number of macrophages/microglia and peripheral infiltrating of neutrophils and lowered the level of the proinflammatory cytokines interleukin-6 and tumor necrosis factor ? in the lesioned cortex. Osthole-treated mice had fewer TUNEL+ apoptotic neurons surrounding the lesion than controls, indicating increased neuronal survival. CONCLUSIONS: Osthole reduced secondary brain damage by suppressing inflammation and apoptosis in a mouse model of stab wound injury. These results suggest a new strategy for promoting neuronal survival and function after neurosurgery to improve long-term patient outcome. Twit Text FOAVip Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury ????J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=26337552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26337552 #FOAvip English Wikipedia <ref>{{Cite pmid|26337552 }}</ref> Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury #MMPMID26337552 Xia Y ; Kong L ; Yao Y ; Jiao Y ; Song J ; Tao Z ; You Z ; Yang J J Neuroinflammation 2015[Sep]; 12 (ä): 155 PMID26337552 show ga BACKGROUND: Neuroendoscopy is an innovative technique for neurosurgery that can nonetheless result in traumatic brain injury. The accompanying neuroinflammation may lead to secondary tissue damage, which is the major cause of delayed neuronal death after surgery. The present study investigated the capacity of osthole to prevent secondary brain injury and the underlying mechanism of action in a mouse model of stab wound injury. METHODS: A mouse model of cortical stab wound injury was established by inserting a needle into the cerebral cortex for 20 min to mimic neuroendoscopy. Mice received an intraperitoneal injection of osthole 30 min after surgery and continued for 14 days. Neurological severity was evaluated 12 h and up to 21 days after the trauma. Brains were collected 3-21 days post-injury for histological analysis, immunocytochemistry, quantitative real-time PCR, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and enzyme-linked immunosorbent assays. RESULTS: Neurological function improved in mice treated with osthole and was accompanied by reduced brain water content and accelerated wound closure relative to untreated mice. Osthole treatment reduced the number of macrophages/microglia and peripheral infiltrating of neutrophils and lowered the level of the proinflammatory cytokines interleukin-6 and tumor necrosis factor ? in the lesioned cortex. Osthole-treated mice had fewer TUNEL+ apoptotic neurons surrounding the lesion than controls, indicating increased neuronal survival. CONCLUSIONS: Osthole reduced secondary brain damage by suppressing inflammation and apoptosis in a mouse model of stab wound injury. These results suggest a new strategy for promoting neuronal survival and function after neurosurgery to improve long-term patient outcome. |*Brain Injuries/complications/drug therapy/pathology [MESH] |Analysis of Variance [MESH] |Animals [MESH] |Brain Edema/etiology/prevention & control [MESH] |Caspase 3/metabolism [MESH] |Cerebral Cortex/*drug effects/pathology [MESH] |Coumarins/*therapeutic use [MESH] |Cytokines [MESH] |Disease Models, Animal [MESH] |Dose-Response Relationship, Drug [MESH] |Encephalitis/etiology/*prevention & control [MESH] |In Situ Nick-End Labeling [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Nerve Tissue Proteins/genetics/metabolism [MESH] |Neurologic Examination [MESH] |Neuroprotective Agents/*therapeutic use [MESH] |Peroxidase/metabolism [MESH] |RNA, Messenger/metabolism [MESH]Osthole confers neuroprotection against cortical stab wound injury and(epmc).pdf DeepDyve Pubget Overpricing