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10.1186/s12931-015-0267-6

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suck abstract from ncbi


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pmid26337978      Respir+Res 2015 ; 16 (1): ä
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  • The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in chronic obstructive pulmonary disease #MMPMID26337978
  • Bakerly ND; Woodcock A; New JP; Gibson JM; Wu W; Leather D; Vestbo J
  • Respir Res 2015[]; 16 (1): ä PMID26337978show ga
  • Background: New treatments need to be evaluated in real-world clinical practice to account for co-morbidities, adherence and polypharmacy. Methods: Patients with chronic obstructive pulmonary disease (COPD), ?40 years old, with exacerbation in the previous 3 years are randomised 1:1 to once-daily fluticasone furoate 100 ?g/vilanterol 25 ?g in a novel dry-powder inhaler versus continuing their existing therapy. The primary endpoint is the mean annual rate of COPD exacerbations; an electronic medical record allows real-time collection and monitoring of endpoint and safety data. Conclusions: The Salford Lung Study is the world?s first pragmatic randomised controlled trial of a pre-licensed medication in COPD. Trial registration: Clinicaltrials.gov identifier NCT01551758.
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