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2015 ; 16
(1
): 101
Nephropedia Template TP
gab.com Text
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English Wikipedia
The Salford Lung Study protocol: a pragmatic, randomised phase III real-world
effectiveness trial in chronic obstructive pulmonary disease
#MMPMID26337978
Bakerly ND
; Woodcock A
; New JP
; Gibson JM
; Wu W
; Leather D
; Vestbo J
Respir Res
2015[Sep]; 16
(1
): 101
PMID26337978
show ga
BACKGROUND: New treatments need to be evaluated in real-world clinical practice
to account for co-morbidities, adherence and polypharmacy. METHODS: Patients with
chronic obstructive pulmonary disease (COPD), ? 40 years old, with exacerbation
in the previous 3 years are randomised 1:1 to once-daily fluticasone furoate 100
?g/vilanterol 25 ?g in a novel dry-powder inhaler versus continuing their
existing therapy. The primary endpoint is the mean annual rate of COPD
exacerbations; an electronic medical record allows real-time collection and
monitoring of endpoint and safety data. CONCLUSIONS: The Salford Lung Study is
the world's first pragmatic randomised controlled trial of a pre-licensed
medication in COPD. TRIAL REGISTRATION: Clinicaltrials.gov identifier
NCT01551758.