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10.1186/s12931-015-0267-6

http://scihub22266oqcxt.onion/10.1186/s12931-015-0267-6
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suck abstract from ncbi


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pmid26337978
      Respir+Res 2015 ; 16 (1 ): 101
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  • The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in chronic obstructive pulmonary disease #MMPMID26337978
  • Bakerly ND ; Woodcock A ; New JP ; Gibson JM ; Wu W ; Leather D ; Vestbo J
  • Respir Res 2015[Sep]; 16 (1 ): 101 PMID26337978 show ga
  • BACKGROUND: New treatments need to be evaluated in real-world clinical practice to account for co-morbidities, adherence and polypharmacy. METHODS: Patients with chronic obstructive pulmonary disease (COPD), ? 40 years old, with exacerbation in the previous 3 years are randomised 1:1 to once-daily fluticasone furoate 100 ?g/vilanterol 25 ?g in a novel dry-powder inhaler versus continuing their existing therapy. The primary endpoint is the mean annual rate of COPD exacerbations; an electronic medical record allows real-time collection and monitoring of endpoint and safety data. CONCLUSIONS: The Salford Lung Study is the world's first pragmatic randomised controlled trial of a pre-licensed medication in COPD. TRIAL REGISTRATION: Clinicaltrials.gov identifier NCT01551758.
  • |Administration, Inhalation [MESH]
  • |Adult [MESH]
  • |Aerosols [MESH]
  • |Androstadienes/*administration & dosage/adverse effects [MESH]
  • |Benzyl Alcohols/*administration & dosage/adverse effects [MESH]
  • |Bronchodilator Agents/*administration & dosage/adverse effects [MESH]
  • |Chlorobenzenes/*administration & dosage/adverse effects [MESH]
  • |Clinical Protocols [MESH]
  • |Disease Progression [MESH]
  • |Drug Administration Schedule [MESH]
  • |Drug Combinations [MESH]
  • |Dry Powder Inhalers [MESH]
  • |Electronic Health Records [MESH]
  • |England [MESH]
  • |Female [MESH]
  • |Glucocorticoids/*administration & dosage/adverse effects [MESH]
  • |Humans [MESH]
  • |Lung/*drug effects/physiopathology [MESH]
  • |Male [MESH]
  • |Pulmonary Disease, Chronic Obstructive/diagnosis/*drug therapy/physiopathology [MESH]
  • |Research Design [MESH]
  • |Time Factors [MESH]


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