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10.1093/gbe/evv141 http://scihub22266oqcxt.onion/10.1093/gbe/evv141 C4558859!4558859 !26232396     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26232396 &cmd=llinks): Failed to open stream: HTTP request failed! 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KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes |pdf=|usr=}}{{26232396 }} gab.com Text KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes JO: Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=26232396 #FOAvip The Krüppel-like factor and specificity protein (KLF/SP) genes play key roles in critical biological processes including stem cell maintenance, cell proliferation, embryonic development, tissue differentiation, and metabolism and their dysregulation has been implicated in a number of human diseases and cancers. Although many KLF/SP genes have been characterized in a handful of bilaterian lineages, little is known about the KLF/SP gene family in nonbilaterians and virtually nothing is known outside the metazoans. Here, we analyze and discuss the origins and evolutionary history of the KLF/SP transcription factor family and associated transactivation/repression domains. We have identified and characterized the complete KLF/SP gene complement from the genomes of 48 species spanning the Eukarya. We have also examined the phylogenetic distribution of transactivation/repression domains associated with this gene family. We report that the origin of the KLF/SP gene family predates the divergence of the Metazoa. Furthermore, the expansion of the KLF/SP gene family is paralleled by diversification of transactivation domains via both acquisitions of pre-existing ancient domains as well as by the appearance of novel domains exclusive to this gene family and is strongly associated with the expansion of cell type complexity. Twit Text FOAVip KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes ????Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=26232396 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26232396 #FOAvip English Wikipedia <ref>{{Cite pmid|26232396 }}</ref> KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes #MMPMID26232396 Presnell JS ; Schnitzler CE ; Browne WE Genome Biol Evol 2015[Jul]; 7 (8 ): 2289-309 PMID26232396 show ga The Krüppel-like factor and specificity protein (KLF/SP) genes play key roles in critical biological processes including stem cell maintenance, cell proliferation, embryonic development, tissue differentiation, and metabolism and their dysregulation has been implicated in a number of human diseases and cancers. Although many KLF/SP genes have been characterized in a handful of bilaterian lineages, little is known about the KLF/SP gene family in nonbilaterians and virtually nothing is known outside the metazoans. Here, we analyze and discuss the origins and evolutionary history of the KLF/SP transcription factor family and associated transactivation/repression domains. We have identified and characterized the complete KLF/SP gene complement from the genomes of 48 species spanning the Eukarya. We have also examined the phylogenetic distribution of transactivation/repression domains associated with this gene family. We report that the origin of the KLF/SP gene family predates the divergence of the Metazoa. Furthermore, the expansion of the KLF/SP gene family is paralleled by diversification of transactivation domains via both acquisitions of pre-existing ancient domains as well as by the appearance of novel domains exclusive to this gene family and is strongly associated with the expansion of cell type complexity. |*Evolution, Molecular [MESH] |*Multigene Family [MESH] |Animals [MESH] |Eukaryota/genetics [MESH] |Kruppel-Like Transcription Factors/chemistry/classification/*genetics [MESH] |Molecular Sequence Data [MESH] |Phylogeny [MESH] |Protein Structure, Tertiary [MESH] |Repressor Proteins/chemistry [MESH] |Sp Transcription Factors/chemistry/classification/*genetics [MESH] |Trans-Activators/chemistry [MESH]KLF/SP Transcription Factor Family Evolution: Expansion, Diversificati(epmc).pdf DeepDyve Pubget Overpricing