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Comparison of palonosetron, granisetron, and ramosetron for the prevention of
postoperative nausea and vomiting after laparoscopic gynecologic surgery: a
prospective randomized trial
#MMPMID26335706
Lee WS
; Lee KB
; Lim S
; Chang YG
BMC Anesthesiol
2015[Sep]; 15
(?): 121
PMID26335706
show ga
BACKGROUND: Selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are
reported to have potent antiemetic effects for postoperative nausea and vomiting
(PONV). The purpose of this study was to prospectively evaluate the efficacy of
palonosetron, granisetron, and ramosetron for the prevention of PONV in patients
undergoing laparoscopic gynecologic surgery. METHODS: In this prospective,
randomized observational study, 105 healthy female patients who were undergoing
laparocopic hystectomy under general anaesthesia were enrolled (clinical trial
number: NCT01752374, www.clinicaltrials.gov ). Patients were divided into three
groups: the palonostron (0.075 mg i.v.; n = 35), the granisetron group (3 mg
i.v.; n = 35), and the ramosetron group (0.3 mg i.v.; n = 35). The treatments
were given before the end of surgery. The incidence of PONV, severity of
nausea/vomiting, and the use of rescue antiemetic requirements during the first
48 h after surgery were evaluated. RESULTS: The overall incidence of PONV was
33.3 % for this series. The number of complete responders at 48 h after the
surgery was 21 (60.0 %) for palonosetron, 24 (68.6 %) for granisetron, and 26
(71.4 %) for ramosetron, representing no statistical difference (P = 0.086).
CONCLUSIONS: There were no significant differences in the overall incidence of
postoperative nausea and vomiting and complete responders for palonosetron,
granisetron and ramosetron group. CLINICAL TRIAL NUMBER: NCT01752374 ,
www.clinicaltrials.gov .
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