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10.1038/srep13497 http://scihub22266oqcxt.onion/10.1038/srep13497 C4558600!4558600 !26333872     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26333872 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Sci+Rep 2015 ; 5 (?): 13497 Nephropedia Template TP {{tp|p=26333872 |t=2015. Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex |pdf=|usr=}}{{26333872 }} gab.com Text Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26333872 #FOAvip Accumulating evidence suggests a pivotal role of PDGFRß positive cells, a specific marker for central nervous system (CNS) pericytes, in tissue scarring. Identification of cells that contribute to tissue reorganization in the CNS upon injury is a crucial step to develop novel treatment strategies in regenerative medicine. It has been shown that pericytes contribute to scar formation in the spinal cord. It is further known that ischemia initially triggers pericyte loss in vivo, whilst brain trauma is capable of inducing pericyte detachment from cerebral vessels. These data point towards a significant role of pericytes in CNS injury. The temporal and spatial dynamics of PDGFRß cells and their responses in traumatic brain injury are poorly understood. Here we show that PDGFRß positive cells initially decline in the acute phase following experimental traumatic brain injury. However, PDGFRß positive cells increase significantly in the trauma zone days after brain injury. Using various pericyte markers we identify these cells to be pericytes that are demarcated by reactive gliosis. Our data indicate that brain trauma causes a biphasic response of pericytes in the early phase of brain trauma that may be of relevance for the understanding of pathological cellular responses in traumatic brain injury. Twit Text FOAVip Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26333872 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26333872 #FOAvip English Wikipedia <ref>{{Cite pmid|26333872 }}</ref> Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex #MMPMID26333872 Zehendner CM ; Sebastiani A ; Hugonnet A ; Bischoff F ; Luhmann HJ ; Thal SC Sci Rep 2015[Sep]; 5 (?): 13497 PMID26333872 show ga Accumulating evidence suggests a pivotal role of PDGFRß positive cells, a specific marker for central nervous system (CNS) pericytes, in tissue scarring. Identification of cells that contribute to tissue reorganization in the CNS upon injury is a crucial step to develop novel treatment strategies in regenerative medicine. It has been shown that pericytes contribute to scar formation in the spinal cord. It is further known that ischemia initially triggers pericyte loss in vivo, whilst brain trauma is capable of inducing pericyte detachment from cerebral vessels. These data point towards a significant role of pericytes in CNS injury. The temporal and spatial dynamics of PDGFRß cells and their responses in traumatic brain injury are poorly understood. Here we show that PDGFRß positive cells initially decline in the acute phase following experimental traumatic brain injury. However, PDGFRß positive cells increase significantly in the trauma zone days after brain injury. Using various pericyte markers we identify these cells to be pericytes that are demarcated by reactive gliosis. Our data indicate that brain trauma causes a biphasic response of pericytes in the early phase of brain trauma that may be of relevance for the understanding of pathological cellular responses in traumatic brain injury. |Animals [MESH] |Brain Injuries/*metabolism/*pathology [MESH] |Cerebral Cortex/metabolism/*pathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Pericytes/*pathology [MESH]Traumatic brain injury results in rapid pericyte loss followed by reac(epmc).pdf DeepDyve Pubget Overpricing