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10.1038/bcj.2015.63 http://scihub22266oqcxt.onion/10.1038/bcj.2015.63 C4558588!4558588 !26252788     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26252788 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood+Cancer+J 2015 ; 5 (8 ): e335 Nephropedia Template TP {{tp|p=26252788 |t=2015. A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis |pdf=|usr=}}{{26252788 }} gab.com Text A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis JO: Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=26252788 #FOAvip In this phase 2 open-label randomized study, 31 patients with intermediate-2 or high-risk myelofibrosis received fedratinib 300, 400 or 500?mg once daily in consecutive 4-week cycles. Mean spleen volume reductions at 12 weeks (primary end point) were 30.3% (300?mg), 33.1% (400?mg) and 43.3% (500?mg). Spleen response rates (patients achieving ?35% spleen reduction) at 12/24 weeks were 30%/30% (300?mg), 50%/60% (400?mg) and 64%/55% (500?mg), respectively. By 4 weeks, improvements in myelofibrosis (MF)-associated symptoms were observed. At 48 weeks, 68% of patients remained on fedratinib and 16% had discontinued because of adverse events (AEs). Common grade 3/4 AEs were anemia (58%), fatigue (13%), diarrhea (13%), vomiting (10%) and nausea (6%). Serious AEs included one case of reversible hepatic failure and one case of Wernicke's encephalopathy (after analysis cutoff). Fedratinib treatment led to reduced STAT3 phosphorylation but no meaningful change in JAK2V617F allele burden. Significant modulation (P<0.05, adjusted for multiple comparisons) of 28 cytokines was observed, many of which correlated with spleen reduction. These data confirm the clinical activity of fedratinib in MF. After the analysis cutoff date, additional reports of Wernicke's encephalopathy in other fedratinib trials led to discontinuation of the sponsored clinical development program. Twit Text FOAVip A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis ????Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=26252788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26252788 #FOAvip English Wikipedia <ref>{{Cite pmid|26252788 }}</ref> A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis #MMPMID26252788 Pardanani A ; Tefferi A ; Jamieson C ; Gabrail NY ; Lebedinsky C ; Gao G ; Liu F ; Xu C ; Cao H ; Talpaz M Blood Cancer J 2015[Aug]; 5 (8 ): e335 PMID26252788 show ga In this phase 2 open-label randomized study, 31 patients with intermediate-2 or high-risk myelofibrosis received fedratinib 300, 400 or 500?mg once daily in consecutive 4-week cycles. Mean spleen volume reductions at 12 weeks (primary end point) were 30.3% (300?mg), 33.1% (400?mg) and 43.3% (500?mg). Spleen response rates (patients achieving ?35% spleen reduction) at 12/24 weeks were 30%/30% (300?mg), 50%/60% (400?mg) and 64%/55% (500?mg), respectively. By 4 weeks, improvements in myelofibrosis (MF)-associated symptoms were observed. At 48 weeks, 68% of patients remained on fedratinib and 16% had discontinued because of adverse events (AEs). Common grade 3/4 AEs were anemia (58%), fatigue (13%), diarrhea (13%), vomiting (10%) and nausea (6%). Serious AEs included one case of reversible hepatic failure and one case of Wernicke's encephalopathy (after analysis cutoff). Fedratinib treatment led to reduced STAT3 phosphorylation but no meaningful change in JAK2V617F allele burden. Significant modulation (P<0.05, adjusted for multiple comparisons) of 28 cytokines was observed, many of which correlated with spleen reduction. These data confirm the clinical activity of fedratinib in MF. After the analysis cutoff date, additional reports of Wernicke's encephalopathy in other fedratinib trials led to discontinuation of the sponsored clinical development program. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Antineoplastic Agents/adverse effects/pharmacokinetics/*therapeutic use [MESH] |Cytokines/blood [MESH] |Dose-Response Relationship, Drug [MESH] |Female [MESH] |Gene Frequency [MESH] |Humans [MESH] |Janus Kinase 2/antagonists & inhibitors/genetics [MESH] |Male [MESH] |Middle Aged [MESH] |Mutation, Missense [MESH] |Primary Myelofibrosis/blood/*drug therapy/genetics [MESH] |Pyrrolidines/adverse effects/pharmacokinetics/*therapeutic use [MESH] |Spleen/drug effects [MESH] |Sulfonamides/adverse effects/pharmacokinetics/*therapeutic use [MESH]A phase 2 randomized dose-ranging study of the JAK2-selective inhibito(epmc).pdf DeepDyve Pubget Overpricing