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10.1038/cddis.2015.211 http://scihub22266oqcxt.onion/10.1038/cddis.2015.211 C4558504!4558504 !26270350     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26270350 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2015 ; 6 (8 ): e1856 Nephropedia Template TP {{tp|p=26270350 |t=2015. AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages |pdf=|usr=}}{{26270350 }} gab.com Text AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26270350 #FOAvip Reticular dysgenesis is a human severe combined immunodeficiency that is primarily characterized by profound neutropenia and lymphopenia. The condition is caused by mutations in the adenylate kinase 2 (AK2) gene, resulting in the loss of mitochondrial AK2 protein expression. AK2 regulates the homeostasis of mitochondrial adenine nucleotides (ADP, ATP and AMP) by catalyzing the transfer of high-energy phosphate. Our present results demonstrate that AK2-knocked-down progenitor cells have poor proliferative and survival capacities and are blocked in their differentiation toward lymphoid and granulocyte lineages. We also observed that AK2 deficiency impaired mitochondrial function in general and oxidative phosphorylation in particular - showing that AK2 is critical in the control of energy metabolism. Loss of AK2 disrupts this regulation and leads to a profound block in lymphoid and myeloid cell differentiation. Twit Text FOAVip AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26270350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26270350 #FOAvip English Wikipedia <ref>{{Cite pmid|26270350 }}</ref> AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages #MMPMID26270350 Six E ; Lagresle-Peyrou C ; Susini S ; De Chappedelaine C ; Sigrist N ; Sadek H ; Chouteau M ; Cagnard N ; Fontenay M ; Hermine O ; Chomienne C ; Reynier P ; Fischer A ; André-Schmutz I ; Gueguen N ; Cavazzana M Cell Death Dis 2015[Aug]; 6 (8 ): e1856 PMID26270350 show ga Reticular dysgenesis is a human severe combined immunodeficiency that is primarily characterized by profound neutropenia and lymphopenia. The condition is caused by mutations in the adenylate kinase 2 (AK2) gene, resulting in the loss of mitochondrial AK2 protein expression. AK2 regulates the homeostasis of mitochondrial adenine nucleotides (ADP, ATP and AMP) by catalyzing the transfer of high-energy phosphate. Our present results demonstrate that AK2-knocked-down progenitor cells have poor proliferative and survival capacities and are blocked in their differentiation toward lymphoid and granulocyte lineages. We also observed that AK2 deficiency impaired mitochondrial function in general and oxidative phosphorylation in particular - showing that AK2 is critical in the control of energy metabolism. Loss of AK2 disrupts this regulation and leads to a profound block in lymphoid and myeloid cell differentiation. |Adenine Nucleotides/metabolism [MESH] |Adenylate Kinase/deficiency/*genetics [MESH] |Antigens, CD34/genetics/metabolism [MESH] |Cell Differentiation [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Gene Knockdown Techniques [MESH] |HL-60 Cells [MESH] |Humans [MESH] |Leukopenia/enzymology/*genetics/pathology [MESH] |Lymphocytes/*enzymology/pathology [MESH] |Mitochondria/enzymology/*genetics/pathology [MESH] |Mutation [MESH] |Neutrophils/*enzymology/pathology [MESH] |Oxidative Phosphorylation [MESH] |Primary Cell Culture [MESH] |Severe Combined Immunodeficiency/enzymology/*genetics/pathology [MESH]AK2 deficiency compromises the mitochondrial energy metabolism require(epmc).pdf DeepDyve Pubget Overpricing