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10.1038/cddis.2015.204 http://scihub22266oqcxt.onion/10.1038/cddis.2015.204 C4558497!4558497 !26247731     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26247731 &cmd=llinks): Failed to open stream: HTTP request failed! 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Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview |pdf=|usr=}}{{26247731 }} gab.com Text Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26247731 #FOAvip Infection by human immunodeficiency virus-1 (HIV-1) is associated with a progressive decrease in CD4 T-cell numbers and the consequent collapse of host immune defenses. The major pathogenic mechanism of AIDS is the massive apoptotic destruction of the immunocompetent cells, including uninfected cells. The latter process, also known as by-stander killing, operates by various mechanisms one of which involves the formation of syncytia which undergo cell death by following a complex pathway. We present here a detailed and curated map of the syncytial apoptosis signaling network, aimed at simplifying the whole mechanism that we have characterized at the molecular level in the last 15 years. The map was created using Systems Biology Graphical Notation language with the help of CellDesigner software and encompasses 36 components (proteins/genes) and 54 interactions. The simplification of this complex network paves the way for the development of novel therapeutic strategies to eradicate HIV-1 infection. Agents that induce the selective death of HIV-1-elicited syncytia might lead to the elimination of viral reservoirs and hence constitute an important complement to current antiretroviral therapies. Twit Text FOAVip Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26247731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26247731 #FOAvip English Wikipedia <ref>{{Cite pmid|26247731 }}</ref> Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview #MMPMID26247731 Nardacci R ; Perfettini JL ; Grieco L ; Thieffry D ; Kroemer G ; Piacentini M Cell Death Dis 2015[Aug]; 6 (8 ): e1846 PMID26247731 show ga Infection by human immunodeficiency virus-1 (HIV-1) is associated with a progressive decrease in CD4 T-cell numbers and the consequent collapse of host immune defenses. The major pathogenic mechanism of AIDS is the massive apoptotic destruction of the immunocompetent cells, including uninfected cells. The latter process, also known as by-stander killing, operates by various mechanisms one of which involves the formation of syncytia which undergo cell death by following a complex pathway. We present here a detailed and curated map of the syncytial apoptosis signaling network, aimed at simplifying the whole mechanism that we have characterized at the molecular level in the last 15 years. The map was created using Systems Biology Graphical Notation language with the help of CellDesigner software and encompasses 36 components (proteins/genes) and 54 interactions. The simplification of this complex network paves the way for the development of novel therapeutic strategies to eradicate HIV-1 infection. Agents that induce the selective death of HIV-1-elicited syncytia might lead to the elimination of viral reservoirs and hence constitute an important complement to current antiretroviral therapies. |Apoptosis/genetics [MESH] |Bystander Effect/genetics [MESH] |CD4 Antigens/genetics/metabolism [MESH] |CD4-Positive T-Lymphocytes/*metabolism/pathology [MESH] |Cell Fusion [MESH] |Gene Expression Regulation [MESH] |Giant Cells/*metabolism/pathology [MESH] |HIV Envelope Protein gp160/genetics/*metabolism [MESH] |HIV Infections/genetics/*metabolism/pathology/virology [MESH] |HIV-1/genetics/*metabolism/pathogenicity [MESH] |Host-Pathogen Interactions/genetics [MESH] |Humans [MESH] |Protein Interaction Mapping [MESH] |Receptors, CXCR4/genetics/metabolism [MESH] |Receptors, Purinergic/genetics/metabolism [MESH]Syncytial apoptosis signaling network induced by the HIV-1 envelope gl(epmc).pdf DeepDyve Pubget Overpricing