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10.1038/cti.2015.16 http://scihub22266oqcxt.onion/10.1038/cti.2015.16 C4558438!4558438!26366286     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Immunology 2015 ; 4 (8): e40- Nephropedia Template TP {{tp|p=26366286|t=2015. Adoptive T-cell therapy for fungal infections in haematology patients |pdf=|usr=}}{{26366286}} gab.com Text Adoptive T-cell therapy for fungal infections in haematology patients JO: Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26366286 #FOAvip The prolonged immune deficiency resulting from haematopoietic stem cell transplant and chemotherapy predisposes to a high risk of invasive fungal infections. Despite the recent advances in molecular diagnostic testing, early initiation of pre-emptive antifungal therapy and the use of combination pharmacotherapy, mortality from invasive mould infections remain high among recipients of allogeneic stem cell transplant. The increasing incidences of previously rare and drug-resistant strains of fungi present a further clinical challenge. Therefore, there is a need for novel strategies to combat fungal infections in the immunocompromised. Adoptive therapy using in vitro-expanded fungus-specific CD4 cells of the Th-1 type has shown clinical efficacy in murine studies and in a small human clinical study. Several techniques for the isolation and expansion of fungus-specific T cells have been successfully applied. Here we discuss the incidence and changing patterns of invasive fungal diseases, clinical evidence supporting the role of T cells in fungal immunity, methods to expand fungus-specific T cells in the laboratory and considerations surrounding the use of T cells for fungal immunotherapy. Twit Text FOAVip Adoptive T-cell therapy for fungal infections in haematology patients ????Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26366286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26366286 #FOAvip English Wikipedia <ref>{{Cite pmid|26366286}}</ref> Adoptive T-cell therapy for fungal infections in haematology patients #MMPMID26366286 Deo SS; Gottlieb DJ Clin Transl Immunology 2015[Aug]; 4 (8): e40- PMID26366286show ga The prolonged immune deficiency resulting from haematopoietic stem cell transplant and chemotherapy predisposes to a high risk of invasive fungal infections. Despite the recent advances in molecular diagnostic testing, early initiation of pre-emptive antifungal therapy and the use of combination pharmacotherapy, mortality from invasive mould infections remain high among recipients of allogeneic stem cell transplant. The increasing incidences of previously rare and drug-resistant strains of fungi present a further clinical challenge. Therefore, there is a need for novel strategies to combat fungal infections in the immunocompromised. Adoptive therapy using in vitro-expanded fungus-specific CD4 cells of the Th-1 type has shown clinical efficacy in murine studies and in a small human clinical study. Several techniques for the isolation and expansion of fungus-specific T cells have been successfully applied. Here we discuss the incidence and changing patterns of invasive fungal diseases, clinical evidence supporting the role of T cells in fungal immunity, methods to expand fungus-specific T cells in the laboratory and considerations surrounding the use of T cells for fungal immunotherapy. äAdoptive T-cell therapy for fungal infections in haematology patients (epmc).pdf DeepDyve Pubget Overpricing