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Participation of WNT and ?-Catenin in Physiological and Pathological Endometrial
Changes: Association with Angiogenesis
#MMPMID26366420
Kiewisz J
; Wasniewski T
; Kmiec Z
Biomed Res Int
2015[]; 2015
(?): 854056
PMID26366420
show ga
WNT proteins are involved in embryonic development, sex determination, stem cell
recruitment, angiogenesis, and cancer. They take part in morphological changes in
the endometrium during development, regulate processes of endometrial
proliferation and differentiation. This review presents current knowledge about
implication of WNT proteins and ?-catenin in physiological endometrial functions
as well as their involvement in uterine carcinogenesis. Influence of WNT proteins
on the formation of blood vessel, taking place both under healthy and
pathological conditions, is also considered. Participation of WNT proteins,
?-catenin, and inhibitors and inducers of WNT signaling in the process of
endometrial angiogenesis is largely unknown. Thus, confirmation of their local
and systemic participation in the process of endometrial angiogenesis may in the
long term help to establish new diagnostic and therapeutic approaches in
conditions associated with the pathology of the female reproductive system.
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