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10.1038/bmt.2015.127

http://scihub22266oqcxt.onion/10.1038/bmt.2015.127
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C4558298!4558298!26030046
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suck abstract from ncbi


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pmid26030046      Bone+Marrow+Transplant 2015 ; 50 (9): 1212-6
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  • Arrhythmias in the Setting of Hematopoietic Cell Transplants #MMPMID26030046
  • Tonorezos ES; Stillwell EE; Calloway JJ; Glew T; Wessler JD; Rebolledo BJ; Pham A; Steingart RM; Lazarus H; Gale RP; Jakubowski AA; Schaffer WL
  • Bone Marrow Transplant 2015[Sep]; 50 (9): 1212-6 PMID26030046show ga
  • Prior studies report 9?27% of persons receiving a hematopoietic cell transplant develop arrhythmias, but the effect on outcomes is largely unknown. We reviewed data from 1177 consecutive patients {greater than or equal to}40 years old receiving a hematopoietic cell transplant at one center during 1999?2009. Transplant indication was predominately leukemia, lymphoma and multiple myeloma. Overall, 104 patients were found to have clinically significant arrhythmia: 43 prior to and 61 following transplant. Post-transplant arrhythmias were most frequently atrial fibrillation(N=30), atrial flutter(N=7) and supraventricular tachycardia(N=11). Subjects with an arrhythmia post-transplant were more likely to have longer median hospital stays (32 days vs 23, P=<.001,) a greater probability of an ICU admission (52% vs 7%; P<.001), more inhospital deaths (28% vs 3%, P<0.001), and more deaths within one year of transplant (41% vs 15%; P<0.001) than patients without arrhythmia at any time. In a multivariate model including age at transplant, diagnosis, history of pre-transplant arrhythmia, and transplant-related variables, post-transplant arrhythmia was associated with a greater risk of death within a year of transplant (OR 3.5, 95% CI: 2.1, 5.9; P < 0.001). Our data suggest arrhythmias after transplants are associated with significant morbidity and mortality. A prospective study of arrhythmia in the transplant setting is warranted.
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