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2015 ; 5
(4
): 28406
Nephropedia Template TP
gab.com Text
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English Wikipedia
Association of clinical signs and symptoms of Ebola viral disease with case
fatality: a systematic review and meta-analysis
#MMPMID26333864
Moole H
; Chitta S
; Victor D
; Kandula M
; Moole V
; Ghadiam H
; Akepati A
; Yerasi C
; Uppu A
; Dharmapuri S
; Boddireddy R
; Fischer J
; Lynch T
J Community Hosp Intern Med Perspect
2015[]; 5
(4
): 28406
PMID26333864
show ga
BACKGROUND: Ebola virus disease (EVD) is a public health emergency of
international concern. There is limited laboratory and clinical data available on
patients with EVD. This is a meta-analysis to assess the utility of clinical
signs, symptoms, and laboratory data in predicting mortality in EVD. AIM: To
assess the utility of clinical signs, symptoms, and laboratory data in predicting
mortality in EVD. METHOD: Study selection criterion: EVD articles with more than
35 EVD cases that described the clinical features were included. Data collection
and extraction: Articles were searched in Medline, PubMed, Ovid journals, and CDC
and WHO official websites. STATISTICAL METHODS: Pooled proportions were
calculated using DerSimonian Laird method (random effects model). RESULTS:
Initial search identified 634 reference articles, of which 67 were selected and
reviewed. Data were extracted from 10 articles (N=5,792) of EVD which met the
inclusion criteria. Bleeding events (64.5% vs. 25.1%), abdominal pain (58.3% vs.
37.5%), vomiting (60.8% vs. 31.7%), diarrhea (69.9% vs. 37.8%), cough (31.6% vs.
22.3%), sore throat (47.7% vs. 19.8%), and conjunctivitis (39.3% vs. 20.3%) were
more often present in pooled proportion of fatal cases as compared to EVD
survivors. CONCLUSIONS: Clinical features of EVD that may be associated with
higher mortality include bleeding events, vomiting, diarrhea, abdominal pain,
cough, sore throat, and conjunctivitis. These patients should be identified
promptly, and appropriate management should be instituted immediately.