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MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by
targeting ZEB2 and MACC1/Met/Akt signaling
#MMPMID25945841
Huang N
; Wu Z
; Lin L
; Zhou M
; Wang L
; Ma H
; Xia J
; Bin J
; Liao Y
; Liao W
Oncotarget
2015[Jun]; 6
(17
): 15222-34
PMID25945841
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MicroRNAs (miRNAs) are involved in the epithelial-mesenchymal transition (EMT)
process and are associated with metastasis in gastric cancer (GC). MiR-338-3p has
been reported to be aberrantly expressed in GC. In the present study, we show
that miR-338-3p inhibited the migration and invasion of GC cells in vitro.
Knocking down miR-338-3p in GC cells led to mesenchymal-like changes. MiR-338-3p
influenced the expression of the EMT-associated proteins by upregulating the
epithelial marker E-cadherin and downregulating the mesenchymal markers,
N-cadherin, fibronectin, and vimentin. In terms of mechanism, miR-338-3p directly
targeted zinc finger E-box-binding protein 2 (ZEB2) and metastasis-associated in
colon cancer-1 (MACC1). MiR-338-3p repressed the Met/Akt pathway after MACC1
inhibition. Reintroduction of ZEB2 and MACC1 reversed miR-338-3p-induced EMT
suppression. Consistently, inverse correlations were also observed between the
expression of miR-338-3p and ZEB2 or MACC1 in human GC tissue samples. In
conclusion, miR-338-3p inhibited the EMT progression in GC cells by targeting
ZEB2 and MACC1/Met/Akt signaling.
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