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10.1371/journal.pbio.1002229 http://scihub22266oqcxt.onion/10.1371/journal.pbio.1002229 C4558032!4558032!26331877     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Biol 2015 ; 13 (9): ä Nephropedia Template TP {{tp|p=26331877|t=2015. Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus |pdf=|usr=}}{{26331877}} gab.com Text Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus JO: PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=26331877 #FOAvip Bacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and is widely accepted as playing a crucial role in disease pathology. To understand the relationship between toxicity and bacterial virulence in greater depth, we studied two sequenced collections of the major human pathogen Staphylococcus aureus and found an unexpected inverse correlation between bacterial toxicity and disease severity. By applying a functional genomics approach, we identified several novel toxicity-affecting loci responsible for the wide range in toxic phenotypes observed within these collections. To understand the apparent higher propensity of low toxicity isolates to cause bacteraemia, we performed several functional assays, and our findings suggest that within-host fitness differences between high- and low-toxicity isolates in human serum is a contributing factor. As invasive infections, such as bacteraemia, limit the opportunities for onward transmission, highly toxic strains could gain an additional between-host fitness advantage, potentially contributing to the maintenance of toxicity at the population level. Our results clearly demonstrate how evolutionary trade-offs between toxicity, relative fitness, and transmissibility are critical for understanding the multifaceted nature of bacterial virulence. Twit Text FOAVip Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus ????PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=26331877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26331877 #FOAvip English Wikipedia <ref>{{Cite pmid|26331877}}</ref> Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus #MMPMID26331877 Laabei M; Uhlemann AC; Lowy FD; Austin ED; Yokoyama M; Ouadi K; Feil E; Thorpe HA; Williams B; Perkins M; Peacock SJ; Clarke SR; Dordel J; Holden M; Votintseva AA; Bowden R; Crook DW; Young BC; Wilson DJ; Recker M; Massey RC PLoS Biol 2015[Sep]; 13 (9): ä PMID26331877show ga Bacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and is widely accepted as playing a crucial role in disease pathology. To understand the relationship between toxicity and bacterial virulence in greater depth, we studied two sequenced collections of the major human pathogen Staphylococcus aureus and found an unexpected inverse correlation between bacterial toxicity and disease severity. By applying a functional genomics approach, we identified several novel toxicity-affecting loci responsible for the wide range in toxic phenotypes observed within these collections. To understand the apparent higher propensity of low toxicity isolates to cause bacteraemia, we performed several functional assays, and our findings suggest that within-host fitness differences between high- and low-toxicity isolates in human serum is a contributing factor. As invasive infections, such as bacteraemia, limit the opportunities for onward transmission, highly toxic strains could gain an additional between-host fitness advantage, potentially contributing to the maintenance of toxicity at the population level. Our results clearly demonstrate how evolutionary trade-offs between toxicity, relative fitness, and transmissibility are critical for understanding the multifaceted nature of bacterial virulence. äEvolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphy(epmc).pdf DeepDyve Pubget Overpricing