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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Aesthet+Dermatol
2015 ; 8
(8
): 22-8
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Cutaneous Safety and Tolerability of a Fixed Combination Clindamycin (1 2%) and
Benzoyl Peroxide (3 75%) Aqueous Gel in Moderate-to-severe Acne Vulgaris
#MMPMID26345297
Webster G
J Clin Aesthet Dermatol
2015[Aug]; 8
(8
): 22-8
PMID26345297
show ga
OBJECTIVE: To investigate the cutaneous safety and tolerability of clindamycin
phosphate 1.2%/benzoyl peroxide 3.75% gel in moderate-to-severe acne patients.
METHODS: A safety assessment of 498 patients with moderate-to-severe acne
receiving clindamycin phosphate 1.2%/benzoyl peroxide 3.75% gel or vehicle for 12
weeks. RESULTS: The vast majority (80-95%) of patients reported no cutaneous
safety or tolerability problems throughout the study. Mean scores for both active
and vehicle were all <1 (where l=mild) and reduced over the duration of the
study. When scaling, erythema, itching, burning, or stinging was reported it was
generally mild. Moderate or severe reactions to clindamycin phosphate
1.2%/benzoyl peroxide 3.75% gel were rare and generally seen early in treatment.
There were eight reports (3.3%) of moderate erythema, four reports (1.7%) of
moderate scaling, three reports (1.2%) of moderate itching, and one report of
moderate burning (0.4%) at Week 4. There was one report (0.4%) of severe erythema
and one report (0.4%) of severe burning (both at Week 4), with one report (0.4%)
of severe stinging at Week 12. There were no substantive differences seen in
cutaneous tolerability among treatment groups and younger patients tended to have
milder reactions. LIMITATIONS: It is not possible to determine the contributions
of the individual active ingredients. CONCLUSION: Clindamycin phosphate
1.2%/benzoyl peroxide 3.75% gel has a favorable safety and tolerability profile
with very low incidence of moderate or severe reactions.