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10.1111/imm.12389

http://scihub22266oqcxt.onion/10.1111/imm.12389
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C4557681!4557681!25244010
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suck abstract from ncbi


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pmid25244010      Immunology 2015 ; 144 (3): 444-52
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  • Contact-dependent suppression of CD4 T-cell activation and proliferation by B cells activated through IgD cross-linking #MMPMID25244010
  • Preciado-Llanes L; Wing JB; Foster RA; Carlring J; Lees A; Read RC; Heath AW
  • Immunology 2015[Mar]; 144 (3): 444-52 PMID25244010show ga
  • Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (?-?-dex) directly inhibit T-cell receptor-induced CD4 T-cell activation, proliferation and cytokine production. This effect was observed in CD4 T cells activated both with and without CD28 co-stimulation. T-cell viability was unaffected, and the T-cell suppressive effect was mediated by contact with IgD-activated purified B cells and not by interleukin-10 or other soluble factors. This is the first evidence of IgD-activated B cells mediating inhibition of activation and proliferation of CD4 T cells in humans.
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