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2013 ; 45
(2
): 94-106
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The effects of pressure on gases in solution: possible insights to improve
microbubble filtration for extracorporeal circulation
#MMPMID23930378
Herbst DP
J Extra Corpor Technol
2013[Jun]; 45
(2
): 94-106
PMID23930378
show ga
Improvements in micropore arterial line filter designs used for extracorporeal
circulation are still needed because microbubbles larger than the rated pore
sizes are being detected beyond the filter outlet. Linked to principles governing
the function of micropore filters, fluid pressures contained in extracorporeal
circuits also influence the behavior of gas bubbles and the extent to which they
are carried in a fluid flow. To better understand the relationship between
pressure and microbubble behavior, two ex vivo test circuits with and without
inline resistance were designed to assess changes in microbubble load with
changes in pressure. Ultrasound Doppler probes were used to measure and compare
the quality and quantity of microbubbles generated in each test circuit. Analysis
of microbubble load was separated into two distinct phases, the time periods
during and immediately after bubble generation. Although microbubble number
decreased similarly in both test circuits, changes in microbubble volume were
significant only in the test circuit with inline resistance. The test circuit
with inline resistance also showed a decrease in the rate of volume transferred
across each ultrasound Doppler probe and the microbubble number and size range
measured in the postbubble generation period. The present research proposes that
fluid pressures contained in extracorporeal circuits may be used to affect gases
in solution as a possible method to improve microbubble filtration during
extracorporeal circulation.