Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1042/CS20150176 http://scihub22266oqcxt.onion/10.1042/CS20150176 C4557398!4557398!25896238     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Sci+(Lond) 2015 ; 129 (Pt 3): 281-90 Nephropedia Template TP {{tp|p=25896238|t=2015. Interleukin 34: a new modulator of human and experimental inflammatory bowel disease |pdf=|usr=}}{{25896238}} gab.com Text Interleukin 34: a new modulator of human and experimental inflammatory bowel disease JO: Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=25896238 #FOAvip IBD (inflammatory bowel disease), where CD (Crohn's disease) and UC (ulcerative colitis) represent the two main forms, are chronic inflammatory conditions of the intestine. Macrophages play a central role in IBD pathogenesis and are regulated by major differentiation factors such as CSF-1 (colony-stimulating factor 1) in homoeostasis and inflammation. IL (interleukin)-34 has recently been discovered as a second ligand for CSF-1R (CSF-1 receptor). However, expression and involvement of IL-34 in IBD remain unknown. In the present paper, we investigated the expression of IL34, CSF1 and their shared receptor CSF1R in normal human ileum and colon, in inflamed and non-inflamed tissues of CD and UC patients, and in a mouse model of experimental colitis. We found distinct expression patterns of IL34 and CSF1 in ileum and colon, with higher IL34 in ileum and, in contrast, higher CSF1 in colon. Furthermore, IL34 and CSF1 expression was increased with inflammation in IBD patients and in experimental colitis. In humans, infiltrating cells of the lamina propria and intestinal epithelial cells expressed IL-34, and TNF-? (tumour necrosis factor ?) regulated IL-34 expression in intestinal epithelial cells through the NF-?B (nuclear factor ?B) pathway. These data demonstrate the expression pattern of IL-34 in ileum and colon and suggest IL-34 as a new modulator of inflammation in IBD. Twit Text FOAVip Interleukin 34: a new modulator of human and experimental inflammatory bowel disease ????Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=25896238 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25896238 #FOAvip English Wikipedia <ref>{{Cite pmid|25896238}}</ref> Interleukin 34: a new modulator of human and experimental inflammatory bowel disease #MMPMID25896238 Zwicker S; Martinez G; Bosma M; Gerling M; Clark R; Majster M; Söderman J; Almer S; Boström E Clin Sci (Lond) 2015[Aug]; 129 (Pt 3): 281-90 PMID25896238show ga IBD (inflammatory bowel disease), where CD (Crohn's disease) and UC (ulcerative colitis) represent the two main forms, are chronic inflammatory conditions of the intestine. Macrophages play a central role in IBD pathogenesis and are regulated by major differentiation factors such as CSF-1 (colony-stimulating factor 1) in homoeostasis and inflammation. IL (interleukin)-34 has recently been discovered as a second ligand for CSF-1R (CSF-1 receptor). However, expression and involvement of IL-34 in IBD remain unknown. In the present paper, we investigated the expression of IL34, CSF1 and their shared receptor CSF1R in normal human ileum and colon, in inflamed and non-inflamed tissues of CD and UC patients, and in a mouse model of experimental colitis. We found distinct expression patterns of IL34 and CSF1 in ileum and colon, with higher IL34 in ileum and, in contrast, higher CSF1 in colon. Furthermore, IL34 and CSF1 expression was increased with inflammation in IBD patients and in experimental colitis. In humans, infiltrating cells of the lamina propria and intestinal epithelial cells expressed IL-34, and TNF-? (tumour necrosis factor ?) regulated IL-34 expression in intestinal epithelial cells through the NF-?B (nuclear factor ?B) pathway. These data demonstrate the expression pattern of IL-34 in ileum and colon and suggest IL-34 as a new modulator of inflammation in IBD. äInterleukin 34: a new modulator of human and experimental inflammatory(epmc).pdf DeepDyve Pubget Overpricing